Nonlinear optical responses of oxidized low-density lipoprotein: Cutoff point for z-scan peak-valley distance

Autor(es)

Pruper de Freitas, Maria Camila ^[1] ; Figueiredo Neto, Antonio Martins ^[2] ; Damasceno, Nagila Raquel ^{[1, 3]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Publ Hlth, Dept Nutr, Av Dr Arnaldo 715, BR-01246904 Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Inst Phys, R Matao 1371, BR-05508090 Sao Paulo, SP - Brazil

^[3] Figueiredo Neto, Antonio Martins, Univ Sao Paulo, Inst Phys, R Matao 1371, BR-05508090 Sao Paulo, SP, Brazil.Pruper de Freitas, Maria Camila, Univ Sao Paulo, Fac Publ Hlth, Dept Nutr, Av Dr Arnaldo 715, BR-01246904 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Photodiagnosis and Photodynamic Therapy; v. 30, JUN 2020.
• Citações Web of Science: 0

Resumo

The development of new methods to assess biomarkers of cardiovascular disease is currently a subject of scientific research. This article broadens our view of nonlinear optical responses of oxidized low density lipoprotein (LDL) evaluated using the Z-scan peak-valley distance and proposes a cutoff point. We investigated the association of peak-valley distance and some cardiovascular risk factors related with sociodemographic, clinical and anthropometric profiles and plasma biomarkers such as lipid and glucose profile, apolipoprotein, lipoprotein subfractions and omega 3 fatty acids. Z-scan analysis was performed using isolated LDL after ultracentrifugation in human blood samples collected after fasting. Peak-valley distance is a parameter that decreases directly depending on the oxidizability of LDL. As peak-valley distance was associated with relevant biomarkers of cardiovascular risk, we tested cutoff points for categorization and the best results were obtained using percentile < 75 (Low(z-sca)(n)) and percentile >= 75 (High(z-scan)). The regression logistic models tested after establishing the cutoff point for peak-valley distance showed that increased levels of plasma high-density lipoprotein cholesterol, apolipoprotein A-I, large high-density lipoprotein subfractions and docosahexaenoic acid are directly associated with High(z-scan). Conversely, high levels of small LDL were associated with decreased odds of presenting High(z-scan) In conclusion, the cutoff point for peak-valley distance was able to identify atherogenic characteristics of LDL and its relationship with some parameters of high-density lipoprotein functionality. (AU)

• Processo FAPESP: 11/12523-2 - Propriedades físico-químicas da LDL e da HDL, marcadores cardiometabólicos e oxidativos podem ser modulados pelo consumo de ômega-3, ômega-6 e ômega-9 em indivíduos adultos?
• Beneficiário: Nágila Raquel Teixeira Damasceno
• Modalidade de apoio: Auxílio à Pesquisa - Regular