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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Influence of magnitude of weight loss on Adipo/lep ratio in adolescents with obesity undergoing multicomponent therapy

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Autor(es):
Martins Ferreira, Yasmin Alaby [1] ; Pelissari Kravchychyn, Ana Claudia [1] ; Ferreira Vicente, Sofia de Castro [1] ; da Silveira Campos, Raquel Munhoz [2, 3] ; Tock, Lian [4] ; Oyama, Lila Missae [1, 5] ; Boldarine, Valter Tadeu [5] ; Landi Masquio, Deborah Cristina [6] ; Damaso, Ana R. [1]
Número total de Autores: 9
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, Escola Paulista Med, Post Grad Program Nutr, Rua Botucatu 862, Vila Clementino, BR-04020050 Sao Paulo, SP - Brazil
[2] Univ Fed Sao Paulo, Dept Biosci, Campus Baixada Santista, Santos, SP - Brazil
[3] Univ Fed Sao Paulo, Post Grad Program Interdisciplinary Hlth Sci, Campus Baixada Santista, Santos, SP - Brazil
[4] Univ Fed Sao Paulo, Post Grad Program Nutr, Sao Paulo, SP - Brazil
[5] Univ Fed Sao Paulo, Escola Paulista Med, Dept Physiol, BR-04023060 Sao Paulo - Brazil
[6] Ctr Univ Sao Camilo, Rua Raul Pompeia, 144 Vila Pompeia, BR-05025010 Sao Paulo, SP - Brazil
Número total de Afiliações: 6
Tipo de documento: Artigo Científico
Fonte: CYTOKINE; v. 131, JUL 2020.
Citações Web of Science: 0
Resumo

Background and aims: The expansion of adipose tissue increases leptin secretion associated with a reduction of adiponectin concentration, which negatively affects health of adolescents with obesity. This study aims to investigate the effects of non-intensive interdisciplinary therapy on cardiometabolic parameters including leptin, adiponectin and adiponectin/leptin ratio as a dependent manner on its magnitude of weight loss reduction. Methods and results: Thirty-eight adolescents (14-19 y.o) were enrolled in an interdisciplinary therapy for 20 weeks. Body composition, biochemical parameters, leptin and adiponectin were measured at baseline and after therapy. The adolescents were divided into two groups according to the magnitude of total weight loss, less than 5% (< 5%-n = 18) or greater than or equal to 5% (>= 5%-n = 20). Leptin decreased in whole group after therapy, while adiponectin, and adiponectin/leptin ratio increased. Additionally, body composition was improved. Only the group who lost >= 5% of body weight could reduce the inflammatory state. Conclusion: The interdisciplinary therapy contributes to improve cardiometabolic parameters that could be involved on inflammation in adolescents with obesity, this improvement occurred mainly when the weight loss is >= 5% of body weight. It could be a target for control the inflammatory process related to obesity in adolescents. (AU)

Processo FAPESP: 17/07372-1 - Novas fronteiras no combate à obesidade: educação em saúde digital como coadjuvante no processo clínico interdisciplinar
Beneficiário:Ana Raimunda Dâmaso
Modalidade de apoio: Auxílio à Pesquisa - Regular