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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Influence of magnitude of weight loss on Adipo/lep ratio in adolescents with obesity undergoing multicomponent therapy

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Author(s):
Martins Ferreira, Yasmin Alaby [1] ; Pelissari Kravchychyn, Ana Claudia [1] ; Ferreira Vicente, Sofia de Castro [1] ; da Silveira Campos, Raquel Munhoz [2, 3] ; Tock, Lian [4] ; Oyama, Lila Missae [1, 5] ; Boldarine, Valter Tadeu [5] ; Landi Masquio, Deborah Cristina [6] ; Damaso, Ana R. [1]
Total Authors: 9
Affiliation:
[1] Univ Fed Sao Paulo, Escola Paulista Med, Post Grad Program Nutr, Rua Botucatu 862, Vila Clementino, BR-04020050 Sao Paulo, SP - Brazil
[2] Univ Fed Sao Paulo, Dept Biosci, Campus Baixada Santista, Santos, SP - Brazil
[3] Univ Fed Sao Paulo, Post Grad Program Interdisciplinary Hlth Sci, Campus Baixada Santista, Santos, SP - Brazil
[4] Univ Fed Sao Paulo, Post Grad Program Nutr, Sao Paulo, SP - Brazil
[5] Univ Fed Sao Paulo, Escola Paulista Med, Dept Physiol, BR-04023060 Sao Paulo - Brazil
[6] Ctr Univ Sao Camilo, Rua Raul Pompeia, 144 Vila Pompeia, BR-05025010 Sao Paulo, SP - Brazil
Total Affiliations: 6
Document type: Journal article
Source: CYTOKINE; v. 131, JUL 2020.
Web of Science Citations: 0
Abstract

Background and aims: The expansion of adipose tissue increases leptin secretion associated with a reduction of adiponectin concentration, which negatively affects health of adolescents with obesity. This study aims to investigate the effects of non-intensive interdisciplinary therapy on cardiometabolic parameters including leptin, adiponectin and adiponectin/leptin ratio as a dependent manner on its magnitude of weight loss reduction. Methods and results: Thirty-eight adolescents (14-19 y.o) were enrolled in an interdisciplinary therapy for 20 weeks. Body composition, biochemical parameters, leptin and adiponectin were measured at baseline and after therapy. The adolescents were divided into two groups according to the magnitude of total weight loss, less than 5% (< 5%-n = 18) or greater than or equal to 5% (>= 5%-n = 20). Leptin decreased in whole group after therapy, while adiponectin, and adiponectin/leptin ratio increased. Additionally, body composition was improved. Only the group who lost >= 5% of body weight could reduce the inflammatory state. Conclusion: The interdisciplinary therapy contributes to improve cardiometabolic parameters that could be involved on inflammation in adolescents with obesity, this improvement occurred mainly when the weight loss is >= 5% of body weight. It could be a target for control the inflammatory process related to obesity in adolescents. (AU)

FAPESP's process: 17/07372-1 - New frontiers in the fight against obesity: digital health education as supporting in the interdisciplinary clinical process
Grantee:Ana Raimunda Dâmaso
Support Opportunities: Regular Research Grants