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Glycemic and lipid homeostasis of offspring from obese rats subimitted to Roux-en-Y gastric bypass

Grant number: 15/11304-6
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): October 01, 2015
Effective date (End): January 31, 2018
Field of knowledge:Biological Sciences - Physiology
Principal Investigator:Antonio Carlos Boschiero
Grantee:Mariana Carla Mendes Brandão
Home Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Obesity is an important public health problem with high prevalence in the adult population as well as in children and adolescents. Evidence indicates that nutrition and maternal metabolism may change the phenotype of children, a phenomenon called "fetal programming". In addition, research has directed the focus to the father, showing that offspring from obese fathers lead to an increase in the body mass index in childhood and in adulthood increasing the risk of development of co- morbidities related to this syndrome. Obesity and its comorbidities can be reversed and even avoided in parents and children with body weight reduction. Bariatric surgery is one of the most effective treatments and offer acceptable results in weight loss and reduction of risks from obesity and its comorbidities. Among surgical procedures, gastric bypass Roux-Y (RYGBP) is one of the most effective techniques for treating diabetic obese patients. The RGYR surgery reduces hyperglycemia and often lead to diabetes remission in patients with morbid obesity and type 2 diabetes, leading to improved insulin sensitivity and beta cell function. However, to date, there are no studies demonstrating that weight loss and metabolic improvement after paternal bariatric surgery can prevent the deleterious effects of obesity on metabolic parameters of the children. Thus, this project will evaluate the glycemic and lipid homeostasis in the offspring (1st generation) of obese males rats undergoing bariatric surgery RYGBP.

Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
BRANDÃO, Mariana Carla Mendes. Effect of Roux-En-Y gastric bypass on liver of male offspring of cafeteria obese rats. 2018. Doctoral Thesis - Universidade Estadual de Campinas, Instituto de Biologia.

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