Lissencephaly in Shih Tzu dogs

Autor(es)

Rodriguez-Sanchez, Diego Noe ^[1] ; Pinto, Giovana Boff Araujo ^[1] ; Thome, Edval Fernando ^[1] ; Machado, Vania Maria de Vasconcelos ^[2] ; Amorim, Rogerio Martins ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ UNESP, Dept Vet Clin, Sch Vet Med & Anim Sci, BR-18618681 Botucatu, SP - Brazil

^[2] Sao Paulo State Univ UNESP, Dept Anim Reprod & Vet Radiol, Sch Vet Med & Anim Sci, BR-18618681 Botucatu, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ACTA VETERINARIA SCANDINAVICA; v. 62, n. 1 JUN 20 2020.
• Citações Web of Science: 0

Resumo

Background Lissencephaly is a brain malformation characterized by smooth and thickened cerebral surface, which may result in structural epilepsy. Lissencephaly is not common in veterinary medicine. Here, we characterize the first cases of lissencephaly in four Shih Tzu dogs, including clinical presentations and findings of magnetic resonance imaging of lissencephaly and several concomitant brain malformations. Case presentation Early-onset acute signs of forebrain abnormalities were observed in all dogs, which were mainly cluster seizures and behavioral alterations. Based on neurological examination, the findings were consistent with symmetrical and bilateral forebrain lesions. Metabolic disorders and inflammatory diseases were excluded. Magnetic resonance imaging for three dogs showed diffuse neocortical agyria and thickened gray matter while one dog had mixed agyria and pachygyria. Other features, such as internal hydrocephalus, supracollicular fluid accumulation, and corpus callosum hypoplasia, were detected concomitantly. Antiepileptic drugs effectively controlled cluster seizures, however, sporadic isolated seizures and signs of forebrain abnormalities, such as behavioral alterations, central blindness, and strabismus persisted. Conclusions Lissencephaly should be considered an important differential diagnosis in Shih Tzu dogs presenting with early-onset signs of forebrain abnormalities, including cluster seizures and behavioral alterations. Magnetic resonance imaging was appropriate forante-mortemdiagnosis of lissencephaly and associated cerebral anomalies. (AU)

• Processo FAPESP: 09/54028-8 - EMU: Laboratório de Diagnóstico por Ressonância Magnética em Medicina Veterinária
• Beneficiário: Luiz Carlos Vulcano
• Modalidade de apoio: Auxílio à Pesquisa - Programa Equipamentos Multiusuários