Targeting gap junctional intercellular communication by hepatocarcinogenic compounds

Autor(es)

Leroy, Kaat ^[1] ; Pieters, Alanah ^[1] ; Tabernilla, Andres ^[1] ; Cooreman, Axelle ^[1] ; Van Campenhout, Raf ^[1] ; Cogliati, Bruno ^[2] ; Vinken, Mathieu ^[1]

Afiliação do(s) autor(es)

^[1] Vrije Univ Brussel, Dept Vitro Toxicol & Dermatocosmetol, Brussels - Belgium

^[2] Univ Sao Paulo, Sch Vet Med & Anim Sci, Dept Pathol, Cidade Univ, Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS; v. 23, n. 6 JUN 2020.
• Citações Web of Science: 0

Resumo

Gap junctions in liver, as in other organs, play a critical role in tissue homeostasis. Inherently, these cellular constituents are major targets for systemic toxicity and diseases, including cancer. This review provides an overview of chemicals that compromise liver gap junctions, in particular biological toxins, organic solvents, pesticides, pharmaceuticals, peroxides, metals and phthalates. The focus in this review is placed upon the mechanistic scenarios that underlie these adverse effects. Further, the potential use of gap junctional activity as anin vitrobiomarker to identify non-genotoxic hepatocarcinogenic chemicals is discussed. (AU)

• Processo FAPESP: 18/10953-9 - As conexinas, panexinas e seus hemi(canais) são novos biomarcadores e alvos terapêuticos no prognóstico e terapia do câncer hepático?
• Beneficiário: Bruno Cogliati
• Modalidade de apoio: Auxílio à Pesquisa - Regular