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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Targeting gap junctional intercellular communication by hepatocarcinogenic compounds

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Author(s):
Leroy, Kaat [1] ; Pieters, Alanah [1] ; Tabernilla, Andres [1] ; Cooreman, Axelle [1] ; Van Campenhout, Raf [1] ; Cogliati, Bruno [2] ; Vinken, Mathieu [1]
Total Authors: 7
Affiliation:
[1] Vrije Univ Brussel, Dept Vitro Toxicol & Dermatocosmetol, Brussels - Belgium
[2] Univ Sao Paulo, Sch Vet Med & Anim Sci, Dept Pathol, Cidade Univ, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Review article
Source: JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS; v. 23, n. 6 JUN 2020.
Web of Science Citations: 0
Abstract

Gap junctions in liver, as in other organs, play a critical role in tissue homeostasis. Inherently, these cellular constituents are major targets for systemic toxicity and diseases, including cancer. This review provides an overview of chemicals that compromise liver gap junctions, in particular biological toxins, organic solvents, pesticides, pharmaceuticals, peroxides, metals and phthalates. The focus in this review is placed upon the mechanistic scenarios that underlie these adverse effects. Further, the potential use of gap junctional activity as anin vitrobiomarker to identify non-genotoxic hepatocarcinogenic chemicals is discussed. (AU)

FAPESP's process: 18/10953-9 - Are connexins, pannexins and their (hemi)channels novel biomarkers and pharmacological targets in the prognosis and therapy of liver cancer?
Grantee:Bruno Cogliati
Support Opportunities: Regular Research Grants