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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

High-risk human papillomavirus in patients with oral leukoplakia and oral squamous cell carcinoma-A multi-centre study in Sweden, Brazil and Romania

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Autor(es):
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Sundberg, Jonas [1] ; Ohman, Jenny [1] ; Korytowska, Magdalena [2] ; Wallstrom, Mats [3] ; Kjeller, Goran [3] ; Andersson, Maria [4] ; Horal, Peter [4] ; Lindh, Magnus [4] ; Giglio, Daniel [5] ; Kovacs, Aniko [6] ; Sand, Lars [7] ; Hirsch, Jan-Michael [8] ; Araujo Ferracini, Lais Magda [9] ; Mamana Fernandes de Souza, Ana Carolina [10] ; Parlatescu, Ioanina [11] ; Dobre, Maria [12] ; Hinescu, Mihail-Eugen [12, 11] ; Braz-Silva, Paulo Henrique [9, 10] ; Tovaru, Serban [11] ; Hasseus, Bengt [1, 13]
Número total de Autores: 20
Afiliação do(s) autor(es):
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[1] Univ Gothenburg, Sahlgrenska Acad, Inst Odontol, Dept Oral Med & Pathol, POB 450, SE-40530 Gothenburg - Sweden
[2] NAL Hosp, Publ Dent Serv, Clin Oral Med, Trollhattan - Sweden
[3] Univ Gothenburg, Sahlgrenska Acad, Inst Odontol, Dept Oral & Maxillofacial Surg, Gothenburg - Sweden
[4] Univ Gothenburg, Sahlgrenska Acad, Inst Biomed, Dept Infect Med, Gothenburg - Sweden
[5] Univ Gothenburg, Sahlgrenska Acad, Inst Clin Sci, Dept Oncol, Gothenburg - Sweden
[6] Sahlgrens Univ Hosp, Dept Clin Pathol, Gothenburg - Sweden
[7] Univ Oslo, Fac Odontol, Dept Oral Biol, Oslo - Norway
[8] Uppsala Univ, Dept Surg Sci Oral & Maxillofacial Surg, Uppsala - Sweden
[9] Univ Sao Paulo, Sch Dent, Dept Stomatol, Sao Paulo - Brazil
[10] Inst Trop Med Sao Paulo, Sch Med, Lab Virol, Sao Paulo - Brazil
[11] Carol Davila Univ Med & Pharm, Fac Dent Med, Oral Pathol Discipline, Bucharest - Romania
[12] Victor Babes Inst Pathol, Bucharest - Romania
[13] Publ Dent Hlth Serv, Clin Oral Med, Gothenburg - Sweden
Número total de Afiliações: 13
Tipo de documento: Artigo Científico
Fonte: ORAL DISEASES; v. 27, n. 2 JUL 2020.
Citações Web of Science: 2
Resumo

Objectives Although causal associations between oral leukoplakia (OL), oral squamous cell carcinoma (OSCC) and high-risk human papillomavirus (HR-HPV) have been speculated upon in several reports, conclusive evidence has not been presented. This study investigates whether the number of cases of HR-HPV in OL has increased over time and whether the prevalence of HR-HPV-positive OL differs in various parts of the world. Patients and Methods A total of 432 patients with OL from Sweden, Brazil and Romania were analysed. Patients were divided into historical (1992-2002) and contemporary (2011-2017) cohorts from the respective countries. Seventeen patients with OL developed oral squamous cell carcinoma (OSCC). A real-time PCR assay, targeting HPV sub-types 6,11,16,18,31,33,35,39,45,52,56,58 and 59, was performed to detect HR-HPV in patients with OL. Results In the Swedish and Romanian cohorts, none of the investigated HPV sub-types were detected. In the Brazilian cohorts, five patients with OL (3%) were positive for HR-HPV, including four patients from the contemporary cohort (HPV 16, 31, 33) and one from the historical cohort (HPV 11). All the cases of OL that transformed into OSCC were HR-HPV-negative, as were the corresponding tumours. Conclusions In summary, the prevalence of HR-HPV in OL is low in all the tested countries, and the incidence has not changed over time. HR-HPV in OL does not seem to be a driver of oncogenesis. (AU)

Processo FAPESP: 15/07727-9 - Avaliação do ambiente imunoregulatório de lesões potencialmente malignas de boca, carcinomas de boca e orofaringe relacionados ou não ao HPV.
Beneficiário:Paulo Henrique Braz da Silva
Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 17/02889-6 - Avaliação do microambiente imunoregulatório em leucoplasias, carcinomas de boca e carcinomas de orofaringe relacionados ou não ao HPV
Beneficiário:Lais Magda Araujo Ferracini
Modalidade de apoio: Bolsas no Brasil - Iniciação Científica