Autor(es):Mostrar menos -

Sundberg, Jonas ^[1] ; Ohman, Jenny ^[1] ; Korytowska, Magdalena ^[2] ; Wallstrom, Mats ^[3] ; Kjeller, Goran ^[3] ; Andersson, Maria ^[4] ; Horal, Peter ^[4] ; Lindh, Magnus ^[4] ; Giglio, Daniel ^[5] ; Kovacs, Aniko ^[6] ; Sand, Lars ^[7] ; Hirsch, Jan-Michael ^[8] ; Araujo Ferracini, Lais Magda ^[9] ; Mamana Fernandes de Souza, Ana Carolina ^[10] ; Parlatescu, Ioanina ^[11] ; Dobre, Maria ^[12] ; Hinescu, Mihail-Eugen ^{[12, 11]} ; Braz-Silva, Paulo Henrique ^{[9, 10]} ; Tovaru, Serban ^[11] ; Hasseus, Bengt ^{[1, 13]}

Afiliação do(s) autor(es):Mostrar menos -

^[1] Univ Gothenburg, Sahlgrenska Acad, Inst Odontol, Dept Oral Med & Pathol, POB 450, SE-40530 Gothenburg - Sweden

^[2] NAL Hosp, Publ Dent Serv, Clin Oral Med, Trollhattan - Sweden

^[3] Univ Gothenburg, Sahlgrenska Acad, Inst Odontol, Dept Oral & Maxillofacial Surg, Gothenburg - Sweden

^[4] Univ Gothenburg, Sahlgrenska Acad, Inst Biomed, Dept Infect Med, Gothenburg - Sweden

^[5] Univ Gothenburg, Sahlgrenska Acad, Inst Clin Sci, Dept Oncol, Gothenburg - Sweden

^[6] Sahlgrens Univ Hosp, Dept Clin Pathol, Gothenburg - Sweden

^[7] Univ Oslo, Fac Odontol, Dept Oral Biol, Oslo - Norway

^[8] Uppsala Univ, Dept Surg Sci Oral & Maxillofacial Surg, Uppsala - Sweden

^[9] Univ Sao Paulo, Sch Dent, Dept Stomatol, Sao Paulo - Brazil

^[10] Inst Trop Med Sao Paulo, Sch Med, Lab Virol, Sao Paulo - Brazil

^[11] Carol Davila Univ Med & Pharm, Fac Dent Med, Oral Pathol Discipline, Bucharest - Romania

^[12] Victor Babes Inst Pathol, Bucharest - Romania

^[13] Publ Dent Hlth Serv, Clin Oral Med, Gothenburg - Sweden

• Tipo de documento: Artigo Científico
• Fonte: ORAL DISEASES; v. 27, n. 2 JUL 2020.
• Citações Web of Science: 2

Resumo

Objectives Although causal associations between oral leukoplakia (OL), oral squamous cell carcinoma (OSCC) and high-risk human papillomavirus (HR-HPV) have been speculated upon in several reports, conclusive evidence has not been presented. This study investigates whether the number of cases of HR-HPV in OL has increased over time and whether the prevalence of HR-HPV-positive OL differs in various parts of the world. Patients and Methods A total of 432 patients with OL from Sweden, Brazil and Romania were analysed. Patients were divided into historical (1992-2002) and contemporary (2011-2017) cohorts from the respective countries. Seventeen patients with OL developed oral squamous cell carcinoma (OSCC). A real-time PCR assay, targeting HPV sub-types 6,11,16,18,31,33,35,39,45,52,56,58 and 59, was performed to detect HR-HPV in patients with OL. Results In the Swedish and Romanian cohorts, none of the investigated HPV sub-types were detected. In the Brazilian cohorts, five patients with OL (3%) were positive for HR-HPV, including four patients from the contemporary cohort (HPV 16, 31, 33) and one from the historical cohort (HPV 11). All the cases of OL that transformed into OSCC were HR-HPV-negative, as were the corresponding tumours. Conclusions In summary, the prevalence of HR-HPV in OL is low in all the tested countries, and the incidence has not changed over time. HR-HPV in OL does not seem to be a driver of oncogenesis. (AU)

• Processo FAPESP: 15/07727-9 - Avaliação do ambiente imunoregulatório de lesões potencialmente malignas de boca, carcinomas de boca e orofaringe relacionados ou não ao HPV.
• Beneficiário: Paulo Henrique Braz da Silva
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 17/02889-6 - Avaliação do microambiente imunoregulatório em leucoplasias, carcinomas de boca e carcinomas de orofaringe relacionados ou não ao HPV
• Beneficiário: Lais Magda Araujo Ferracini
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica