| Full text | |
| Author(s): Show less - |
Sundberg, Jonas
[1]
;
Ohman, Jenny
[1]
;
Korytowska, Magdalena
[2]
;
Wallstrom, Mats
[3]
;
Kjeller, Goran
[3]
;
Andersson, Maria
[4]
;
Horal, Peter
[4]
;
Lindh, Magnus
[4]
;
Giglio, Daniel
[5]
;
Kovacs, Aniko
[6]
;
Sand, Lars
[7]
;
Hirsch, Jan-Michael
[8]
;
Araujo Ferracini, Lais Magda
[9]
;
Mamana Fernandes de Souza, Ana Carolina
[10]
;
Parlatescu, Ioanina
[11]
;
Dobre, Maria
[12]
;
Hinescu, Mihail-Eugen
[12, 11]
;
Braz-Silva, Paulo Henrique
[9, 10]
;
Tovaru, Serban
[11]
;
Hasseus, Bengt
[1, 13]
Total Authors: 20
|
| Affiliation: Show less - | [1] Univ Gothenburg, Sahlgrenska Acad, Inst Odontol, Dept Oral Med & Pathol, POB 450, SE-40530 Gothenburg - Sweden
[2] NAL Hosp, Publ Dent Serv, Clin Oral Med, Trollhattan - Sweden
[3] Univ Gothenburg, Sahlgrenska Acad, Inst Odontol, Dept Oral & Maxillofacial Surg, Gothenburg - Sweden
[4] Univ Gothenburg, Sahlgrenska Acad, Inst Biomed, Dept Infect Med, Gothenburg - Sweden
[5] Univ Gothenburg, Sahlgrenska Acad, Inst Clin Sci, Dept Oncol, Gothenburg - Sweden
[6] Sahlgrens Univ Hosp, Dept Clin Pathol, Gothenburg - Sweden
[7] Univ Oslo, Fac Odontol, Dept Oral Biol, Oslo - Norway
[8] Uppsala Univ, Dept Surg Sci Oral & Maxillofacial Surg, Uppsala - Sweden
[9] Univ Sao Paulo, Sch Dent, Dept Stomatol, Sao Paulo - Brazil
[10] Inst Trop Med Sao Paulo, Sch Med, Lab Virol, Sao Paulo - Brazil
[11] Carol Davila Univ Med & Pharm, Fac Dent Med, Oral Pathol Discipline, Bucharest - Romania
[12] Victor Babes Inst Pathol, Bucharest - Romania
[13] Publ Dent Hlth Serv, Clin Oral Med, Gothenburg - Sweden
Total Affiliations: 13
|
| Document type: | Journal article |
| Source: | ORAL DISEASES; v. 27, n. 2 JUL 2020. |
| Web of Science Citations: | 2 |
| Abstract | |
Objectives Although causal associations between oral leukoplakia (OL), oral squamous cell carcinoma (OSCC) and high-risk human papillomavirus (HR-HPV) have been speculated upon in several reports, conclusive evidence has not been presented. This study investigates whether the number of cases of HR-HPV in OL has increased over time and whether the prevalence of HR-HPV-positive OL differs in various parts of the world. Patients and Methods A total of 432 patients with OL from Sweden, Brazil and Romania were analysed. Patients were divided into historical (1992-2002) and contemporary (2011-2017) cohorts from the respective countries. Seventeen patients with OL developed oral squamous cell carcinoma (OSCC). A real-time PCR assay, targeting HPV sub-types 6,11,16,18,31,33,35,39,45,52,56,58 and 59, was performed to detect HR-HPV in patients with OL. Results In the Swedish and Romanian cohorts, none of the investigated HPV sub-types were detected. In the Brazilian cohorts, five patients with OL (3%) were positive for HR-HPV, including four patients from the contemporary cohort (HPV 16, 31, 33) and one from the historical cohort (HPV 11). All the cases of OL that transformed into OSCC were HR-HPV-negative, as were the corresponding tumours. Conclusions In summary, the prevalence of HR-HPV in OL is low in all the tested countries, and the incidence has not changed over time. HR-HPV in OL does not seem to be a driver of oncogenesis. (AU) | |
| FAPESP's process: | 15/07727-9 - Evaluation of immunoregulatory microenvironment of oral premalignant lesions, squamous cell carcinomas and oropharyngeal carcinomas related to HPV or not. |
| Grantee: | Paulo Henrique Braz da Silva |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 17/02889-6 - Evaluation of immunoregulatory microenvironment of oral premalignant lesions, squamous cell carcinomas and oropharyngeal carcinomas related to HPV or not |
| Grantee: | Lais Magda Araujo Ferracini |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |