Brain white matter microstructure in obese women with binge eating disorder

Autor(es)

Estella, Nara Mendes ^[1] ; Sanches, Liana Guerra ^[2] ; Maranhao, Mara Fernandes ^[1] ; Hoexter, Marcelo Queiroz ^[1] ; Schmidt, Ulrike ^[3] ; Campbell, Iain C. ^[3] ; Amaro, Edson ^[2] ; Claudino, Angelica Medeiros ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo UNIFESP, Dept Psychiat, Eating Disorder Program PROATA, Sao Paulo - Brazil

^[2] Hosp Israelita Albert Einstein, Sao Paulo - Brazil

^[3] Kings Coll London, Inst Psychiat Psychol & Neurosci, London - England

• Tipo de documento: Artigo Científico
• Fonte: EUROPEAN EATING DISORDERS REVIEW; v. 28, n. 5 JUL 2020.
• Citações Web of Science: 0

Resumo

Objective Research on potential brain circuit abnormalities in binge eating disorder (BED) is limited. Here, we assess white matter (WM) microstructure in obese women with BED. Method Diffusion tensor imaging data were acquired, and tract-based spatial statistics used to examine WM in women with BED who were obese (n= 17) compared to normal-weight (NWC) (n= 17) and to women who were obese (OBC) (n= 13). Body mass index (BMI) was a covariate in the analyses. Results The BED group (vs. NWC) had greater axial diffusion (AD) in the forceps minor, anterior thalamic radiation, superior and inferior longitudinal fasciculus, that is, in pathways connecting fronto-limbic regions. Microstructures differences in AD between the BED and OBC groups were seen in fronto-limbic pathways extending to temporoparietal pathways. The BED (vs. OBC) group had greater fractional anisotropy in the forceps minor and greater AD in the superior longitudinal fasciculus, cingulate gyrus, and corpus callosum, consistent with fronto-tempoparietal pathways. Conclusion Women with BED show WM alterations in AD in fronto-limbic and parietal pathways that are important in decision-making processes. As BMI was a covariate in the analyses, alterations in BED may be part of the pathology, but whether they are a cause or effect of illness is unclear. (AU)

• Processo FAPESP: 14/04258-5 - Estudo duplo-cego, randomizado e placebo-controlado sobre os efeitos da estimulação magnética transcraniana repetitiva em pessoas obesas com transtorno de compulsão alimentar
• Beneficiário: Angélica de Medeiros Claudino
• Modalidade de apoio: Auxílio à Pesquisa - Regular