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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Brain white matter microstructure in obese women with binge eating disorder

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Author(s):
Estella, Nara Mendes [1] ; Sanches, Liana Guerra [2] ; Maranhao, Mara Fernandes [1] ; Hoexter, Marcelo Queiroz [1] ; Schmidt, Ulrike [3] ; Campbell, Iain C. [3] ; Amaro, Edson [2] ; Claudino, Angelica Medeiros [1]
Total Authors: 8
Affiliation:
[1] Univ Fed Sao Paulo UNIFESP, Dept Psychiat, Eating Disorder Program PROATA, Sao Paulo - Brazil
[2] Hosp Israelita Albert Einstein, Sao Paulo - Brazil
[3] Kings Coll London, Inst Psychiat Psychol & Neurosci, London - England
Total Affiliations: 3
Document type: Journal article
Source: EUROPEAN EATING DISORDERS REVIEW; v. 28, n. 5 JUL 2020.
Web of Science Citations: 0
Abstract

Objective Research on potential brain circuit abnormalities in binge eating disorder (BED) is limited. Here, we assess white matter (WM) microstructure in obese women with BED. Method Diffusion tensor imaging data were acquired, and tract-based spatial statistics used to examine WM in women with BED who were obese (n= 17) compared to normal-weight (NWC) (n= 17) and to women who were obese (OBC) (n= 13). Body mass index (BMI) was a covariate in the analyses. Results The BED group (vs. NWC) had greater axial diffusion (AD) in the forceps minor, anterior thalamic radiation, superior and inferior longitudinal fasciculus, that is, in pathways connecting fronto-limbic regions. Microstructures differences in AD between the BED and OBC groups were seen in fronto-limbic pathways extending to temporoparietal pathways. The BED (vs. OBC) group had greater fractional anisotropy in the forceps minor and greater AD in the superior longitudinal fasciculus, cingulate gyrus, and corpus callosum, consistent with fronto-tempoparietal pathways. Conclusion Women with BED show WM alterations in AD in fronto-limbic and parietal pathways that are important in decision-making processes. As BMI was a covariate in the analyses, alterations in BED may be part of the pathology, but whether they are a cause or effect of illness is unclear. (AU)

FAPESP's process: 14/04258-5 - A double-blinded, randomized, sham-controlled trial on the effects of repetitive transcranial magnetic stimulation in obese people with binge eating disorder
Grantee:Angélica de Medeiros Claudino
Support Opportunities: Regular Research Grants