Genetic Polymorphisms in ACTN3 Contribute to the Etiology of Bruxism in Children

Autor(es)

Calvano Kuchler, E. ^[1] ; Arid, J. ^[2] ; Palinkas, M. ^[3] ; Ayumi Omori, M. ^[2] ; de Lara, R. M. ^[1] ; Napolitano Goncalves, L. M. ^[3] ; Hallak Regalo, S. C. ^[3] ; Paes Torres Mantovani, C. ^[2] ; Rezende Vieira, A. ^[4] ; Diaz-Serrano, K. ^[2]

Afiliação do(s) autor(es)

^[1] Posit Univ, Sch Hlth Sci, Rua Prof Pedro Viriato Parigot de Souza 5300, Curitiba, Parana - Brazil

^[2] Univ Sao Paulo, Sch Dent Ribeirao Preto, Dept Pediat Dent, Ribeirao Preto, SP - Brazil

^[3] Univ Sao Paulo, Sch Dent Ribeirao Preto, Dept Morphol Fisiol & Basic Patol, Ribeirao Preto - Brazil

^[4] Univ Pittsburgh, Dept Oral Biol, Pittsburgh, PA - USA

• Tipo de documento: Artigo Científico
• Fonte: Journal of Clinical Pediatric Dentistry; v. 44, n. 3, p. 180-184, 2020.
• Citações Web of Science: 0

Resumo

Objective: Bruxism is a condition defined as a masticatory muscle activity with an unexplored genetic background. The aim of this study was to evaluate the association between genetic polymorphisms in ACTN3 and bruxism. Study design: A total of 151 biological-unrelated children, aged 7-12 years were included in a case control ratio of 1:1.5. The data collection was performed during interview and clinical examination. Saliva samples were collected from all children and 3 genetic polymorphisms in the ACTN3 (rs678397, rs1671064 and rs1815739) were selected for genotyping using real time PCR. Pearson chisquare calculation was used to assess Hardy-Weinberg equilibrium and to evaluate the association between genotypes and alleles frequencies for each genetic polymorphism in the co-dominant and recessive models. An alpha of 5% was used. Results: The genetic polymorphisms rs678397, rs1671064 and rs1815739 were associated with bruxism in the co-dominate model and in the recessive model (p<0.05). Allele distribution was also associated with bruxism for the polymorphisms rs678397 and rs1671064 (p<0.05). Conclusion: The genetic polymorphisms rs678397, rs1671064 and rs1815739 in ACTN3 are associated with bruxism and can contribute to the etiology of this condition in children. (AU)

• Processo FAPESP: 15/06866-5 - Avaliação do papel do estrógeno no desenvolvimento dentofacial
• Beneficiário: Erika Calvano Kuchler
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores