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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Genetic Polymorphisms in ACTN3 Contribute to the Etiology of Bruxism in Children

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Author(s):
Calvano Kuchler, E. [1] ; Arid, J. [2] ; Palinkas, M. [3] ; Ayumi Omori, M. [2] ; de Lara, R. M. [1] ; Napolitano Goncalves, L. M. [3] ; Hallak Regalo, S. C. [3] ; Paes Torres Mantovani, C. [2] ; Rezende Vieira, A. [4] ; Diaz-Serrano, K. [2]
Total Authors: 10
Affiliation:
[1] Posit Univ, Sch Hlth Sci, Rua Prof Pedro Viriato Parigot de Souza 5300, Curitiba, Parana - Brazil
[2] Univ Sao Paulo, Sch Dent Ribeirao Preto, Dept Pediat Dent, Ribeirao Preto, SP - Brazil
[3] Univ Sao Paulo, Sch Dent Ribeirao Preto, Dept Morphol Fisiol & Basic Patol, Ribeirao Preto - Brazil
[4] Univ Pittsburgh, Dept Oral Biol, Pittsburgh, PA - USA
Total Affiliations: 4
Document type: Journal article
Source: Journal of Clinical Pediatric Dentistry; v. 44, n. 3, p. 180-184, 2020.
Web of Science Citations: 0
Abstract

Objective: Bruxism is a condition defined as a masticatory muscle activity with an unexplored genetic background. The aim of this study was to evaluate the association between genetic polymorphisms in ACTN3 and bruxism. Study design: A total of 151 biological-unrelated children, aged 7-12 years were included in a case control ratio of 1:1.5. The data collection was performed during interview and clinical examination. Saliva samples were collected from all children and 3 genetic polymorphisms in the ACTN3 (rs678397, rs1671064 and rs1815739) were selected for genotyping using real time PCR. Pearson chisquare calculation was used to assess Hardy-Weinberg equilibrium and to evaluate the association between genotypes and alleles frequencies for each genetic polymorphism in the co-dominant and recessive models. An alpha of 5% was used. Results: The genetic polymorphisms rs678397, rs1671064 and rs1815739 were associated with bruxism in the co-dominate model and in the recessive model (p<0.05). Allele distribution was also associated with bruxism for the polymorphisms rs678397 and rs1671064 (p<0.05). Conclusion: The genetic polymorphisms rs678397, rs1671064 and rs1815739 in ACTN3 are associated with bruxism and can contribute to the etiology of this condition in children. (AU)

FAPESP's process: 15/06866-5 - Evaluation of the role of estrogen in dentofacial development
Grantee:Erika Calvano Kuchler
Support Opportunities: Research Grants - Young Investigators Grants