| Full text | |
| Author(s): |
Calvano Kuchler, E.
[1]
;
Arid, J.
[2]
;
Palinkas, M.
[3]
;
Ayumi Omori, M.
[2]
;
de Lara, R. M.
[1]
;
Napolitano Goncalves, L. M.
[3]
;
Hallak Regalo, S. C.
[3]
;
Paes Torres Mantovani, C.
[2]
;
Rezende Vieira, A.
[4]
;
Diaz-Serrano, K.
[2]
Total Authors: 10
|
| Affiliation: | [1] Posit Univ, Sch Hlth Sci, Rua Prof Pedro Viriato Parigot de Souza 5300, Curitiba, Parana - Brazil
[2] Univ Sao Paulo, Sch Dent Ribeirao Preto, Dept Pediat Dent, Ribeirao Preto, SP - Brazil
[3] Univ Sao Paulo, Sch Dent Ribeirao Preto, Dept Morphol Fisiol & Basic Patol, Ribeirao Preto - Brazil
[4] Univ Pittsburgh, Dept Oral Biol, Pittsburgh, PA - USA
Total Affiliations: 4
|
| Document type: | Journal article |
| Source: | Journal of Clinical Pediatric Dentistry; v. 44, n. 3, p. 180-184, 2020. |
| Web of Science Citations: | 0 |
| Abstract | |
Objective: Bruxism is a condition defined as a masticatory muscle activity with an unexplored genetic background. The aim of this study was to evaluate the association between genetic polymorphisms in ACTN3 and bruxism. Study design: A total of 151 biological-unrelated children, aged 7-12 years were included in a case control ratio of 1:1.5. The data collection was performed during interview and clinical examination. Saliva samples were collected from all children and 3 genetic polymorphisms in the ACTN3 (rs678397, rs1671064 and rs1815739) were selected for genotyping using real time PCR. Pearson chisquare calculation was used to assess Hardy-Weinberg equilibrium and to evaluate the association between genotypes and alleles frequencies for each genetic polymorphism in the co-dominant and recessive models. An alpha of 5% was used. Results: The genetic polymorphisms rs678397, rs1671064 and rs1815739 were associated with bruxism in the co-dominate model and in the recessive model (p<0.05). Allele distribution was also associated with bruxism for the polymorphisms rs678397 and rs1671064 (p<0.05). Conclusion: The genetic polymorphisms rs678397, rs1671064 and rs1815739 in ACTN3 are associated with bruxism and can contribute to the etiology of this condition in children. (AU) | |
| FAPESP's process: | 15/06866-5 - Evaluation of the role of estrogen in dentofacial development |
| Grantee: | Erika Calvano Kuchler |
| Support Opportunities: | Research Grants - Young Investigators Grants |