Erasing gametes to write blastocysts: metabolism as the new player in epigenetic reprogramming

Autor(es)

Marcella Pecora Milazzotto ; Camila Bruna de Lima ; Aldcejam Martins da Fonseca Junior ^[3] ; Erika Cristina dos Santos ^[4] ; Jessica Ispada ^[5]

• Tipo de documento: Artigo Científico
• Fonte: Animal Reproduction; v. 17, n. 3 2020-08-10.

Resumo

Abstract Understanding preimplantation embryonic development is crucial for the improvement of assisted reproductive technologies and animal production. To achieve this goal, it is important to consider that gametes and embryos are highly susceptible to environmental changes. Beyond the metabolic adaptation, the dynamic status imposed during follicular growth and early embryogenesis may create marks that will guide the molecular regulation during prenatal development, and consequently impact the offspring phenotype. In this context, metaboloepigenetics has gained attention, as it investigates the crosstalk between metabolism and molecular control, i.e., how substrates generated by metabolic pathways may also act as players of epigenetic modifications. In this review, we present the main metabolic and epigenetic events of pre-implantation development, and how these systems connect to open possibilities for targeted manipulation of reproductive technologies and animal production systems. (AU)

• Processo FAPESP: 17/18384-0 - Metaboloepigenética: o estudo do desenvolvimento de embriões bovinos sob uma nova ótica
• Beneficiário: Marcella Pecora Milazzotto
• Modalidade de apoio: Auxílio à Pesquisa - Regular