Refractoriness of aggressive behaviour to pharmacological treatment: cortical thickness analysis in autism spectrum disorder

Autor(es)

Gouveia, Flavia Venetucci ^{[1, 2]} ; Germann, Juergen ^{[3, 4]} ; Devenyi, Gabriel A. ^{[5, 4]} ; Morais, Rosa M. C. B. ^{[1, 6]} ; Santos, Ana Paula M. ^[6] ; Fonoff, Erich T. ^[7] ; Hamani, Clement ^{[2, 8, 9]} ; Brentani, Helena ^[6] ; Chakravarty, M. Mallar ^{[5, 4, 10]} ; Martinez, Raquel C. R. ^{[1, 6]}

Afiliação do(s) autor(es)

^[1] Hosp Sirio Libanes, Sao Paulo - Brazil

^[2] Sunnybrook Res Inst, Toronto, ON - Canada

^[3] Univ Hlth Network, Montreal, PQ - Canada

^[4] McGill Univ, Douglas Mental Hlth Univ Inst, CIC, Montreal, PQ - Canada

^[5] McGill Univ, Dept Psychiat, Montreal, PQ - Canada

^[6] Univ Sao Paulo, Med Sch, Dept Psychiat, Sao Paulo - Brazil

^[7] Univ Sao Paulo, Med Sch, Dept Neurol, Div Funct Neurosurg, Inst Psychiat, Sao Paulo - Brazil

^[8] Univ Toronto, Sunnybrook Hlth Sci Ctr, Div Neurosurg, Toronto, ON - Canada

^[9] Sunnybrook Hlth Sci Ctr, Harquail Ctr Neuromodulat, Toronto, ON - Canada

^[10] McGill Univ, Dept Biol & Biomed Engn, Montreal, PQ - Canada

• Tipo de documento: Artigo Científico
• Fonte: BJPSYCH OPEN; v. 6, n. 5 SEP 2020.
• Citações Web of Science: 0

Resumo

Aggressive behaviour is a highly prevalent and devastating condition in autism spectrum disorder resulting in impoverished quality of life. Gold-standard therapies are ineffective in about 30% of patients leading to greater suffering. We investigated cortical thickness in individuals with autism spectrum disorder with pharmacological-treatment-refractory aggressive behaviour compared with those with non-refractory aggressive behaviour and observed a brain-wide pattern of local increased thickness in key areas related to emotional control and overall decreased cortical thickness in those with refractory aggressive behaviour, suggesting refractoriness could be related to specific morphological patterns. Elucidating the neurobiology of refractory aggressive behaviour is crucial to provide insights and potential avenues for new interventions. (AU)

• Processo FAPESP: 13/20602-5 - Análise prospectiva dos resultados funcionais da amigdalotomia bilateral assistencial em pacientes com agressividade refratária
• Beneficiário: Flavia Venetucci Gouveia
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 11/08575-7 - Papel da modulação dopaminérgica no núcleo lateral da amígdala sobre a resposta condicionada de esquiva
• Beneficiário: Raquel Chacon Ruiz Martinez
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 17/10466-8 - Desvendando agressividade: estudo de imagem do cérebro agressivo
• Beneficiário: Flavia Venetucci Gouveia
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado