Active human herpesvirus infections in adults with systemic lupus erythematosus and correlation with the SLEDAI score

Autor(es)

Alex Domingos dos Reis ^[1] ; Cristiane Mudinutti ^[2] ; Murilo de Freitas Peigo ^[3] ; Lucas Lopes Leon ^[4] ; Lilian Tereza Lavras Costallat ^[5] ; Claudio Lucio Rossi ^[6] ; Sandra Cecília Botelho Costa ^[7] ; Sandra Helena Alves Bonon ^[8]

Afiliação do(s) autor(es)

^[1] State University of Campinas. School of Medical Sciences. Laboratory of Virology - Brasil

^[2] State University of Campinas. School of Medical Sciences. Laboratory of Virology - Brasil

^[3] State University of Campinas. School of Medical Sciences. Laboratory of Virology - Brasil

^[4] State University of Campinas. School of Medical Sciences. Laboratory of Virology - Brasil

^[5] State University of Campinas. School of Medical Sciences. Discipline of Rheumatology - Brasil

^[6] State University of Campinas. School of Medical Sciences. Department of Clinical Pathology - Brasil

^[7] State University of Campinas. School of Medical Sciences. Laboratory of Virology - Brasil

^[8] State University of Campinas. School of Medical Sciences. Laboratory of Virology - Brasil

• Tipo de documento: Artigo Científico
• Fonte: ADVANCES IN RHEUMATOLOGY; v. 60, 2020-09-04.

Resumo

Abstract Background: Human herpesviruses (HHVs) are responsible for a significant number of clinical manifestations in systemic lupus erythematous (SLE) patients. The aim of this study was to determine the frequency of active HHV infections in SLE patients and correlating them with disease activity. Methods: Serum samples were collected from 71 SLE patients and their DNAs were extracted and analyzed to detect HHV-DNA viruses using the nucleic acid amplification technique. Results: Fifteen out of the 71 (21.1%) patients tested positive for the HHV-DNA virus. Of them, 11/15 HHV-DNA-positive patients (73.3%) had SLE activity index (SLEDAI - Systemic Lupus Erythematosus Disease Activity Index) ≥8 (p = 0.0001). Active HCMV infection was the mostly frequently observed infection, occurring in 6/15 patients (40%). The frequencies of other active viral infections were 22% for HSV-1, 16.7% for HHV-7, and 5.5% for HSV-2. Viral coinfection (two or more viruses detected in the same sample) occurred in three patients (16.7%). Active HHV infections in SLE patients are more frequent in those with active SLE (≥8), who is at high risk of HHV reactivation and HCMV disease. Conclusion: Viral surveillance is important to identify active HHV infections that can cause clinical symptoms and other complication in SLE patients. (AU)

• Processo FAPESP: 14/11430-9 - Detecção do painel herpesvírus humano pela reação em cadeia da polimerase tipo nested em pacientes com Lúpus Eritematosos Sistêmico
• Beneficiário: Alex Domingos Reis
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica