Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Lycium barbarumpolysaccharide fraction associated with photobiomodulation protects from epithelium thickness and collagen fragmentation in a model of cutaneous photodamage

Texto completo
Autor(es):
Grosso Neves, Lia Mara [1] ; Tim, Carla Roberta [2] ; Floriano, Elaine Medeiros [3] ; da Silva de Avo, Lucimar Retto [4] ; Fernandes, Joao Batista [5] ; Parizotto, Nivaldo Antonio [2, 6, 7] ; Cominetti, Marcia Regina [1]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Fed Sao Carlos, Dept Gerontol, Lab Biol Aging LABEN, BR-13565905 Sao Carlos, SP - Brazil
[2] Brazil Univ, Postgrad Program Biomed Engn, BR-08230030 Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Dept Pathol & Legal Med, BR-14049900 Ribeirao Preto, SP - Brazil
[4] Univ Fed Sao Carlos, Dept Med, BR-13565905 Sao Carlos, SP - Brazil
[5] Univ Fed Sao Carlos, Dept Chem, BR-13565905 Sao Carlos, SP - Brazil
[6] Univ Fed Sao Carlos, Joint Grad Program Phys Therapy, BR-13565905 Sao Carlos, SP - Brazil
[7] Univ Araraquara, Postgrad Program Biotechnol Regenerat Med & Med C, BR-14801340 Araraquara, SP - Brazil
Número total de Afiliações: 7
Tipo de documento: Artigo Científico
Fonte: Lasers in Medical Science; AUG 2020.
Citações Web of Science: 0
Resumo

Ultraviolet radiation (UVR) is the major etiologic agent of cutaneous photoaging, and different strategies are used to prevent and treat this condition. The polysaccharide fraction (LBPF) isolated fromLycium Barbarumfruits (goji berry) contains several active ingredients with antioxidant, immune system modulation, and antitumor effects. In addition, the photobiomodulation (PBM) is widely applied in photoaging treatment. This study investigated the effects of LBPF and PBM against the UVR-induced photodamage in the skin of hairless mice. The mice were photoaged for 6 weeks in a chronic and cumulative exposure regimen using a 300-W incandescent lamp that simulates the UVR effects. From the third to the sixth week of photoaging induction, the animals received topical applications of LBPF and PBM, singly or combined, in different orders (first LBPF and then PBM and inversely), three times per week after each session of photoaging. After completion of experiments, the dorsal region skin was collected for the analysis of thickness, collagen content, and metalloproteinases (MMP) levels. A photoprotective potential against the increase of the epithelium thickness and the fragmentation of the collagen fibers was achieved in the skin of mice treated with LBPF or PBM singly, as well as their combination. All treatments maintained the skin collagen composition, except when PBM was applied after the LBPF. However, no treatment protected against the UVR-induced MMP increase. Taken together, we have shown that the LBPF and PBM promote a photoprotective effect in hairless mice skin against epidermal thickening and low collagen density. Both strategies, singly and combined, can be used to reduce the UVR-induced cutaneous photoaging. (AU)

Processo FAPESP: 13/27021-8 - Efeitos do extrato do fruto de Lycium barbarum L. e do laser vermelho na prevenção e tratamento do fotoenvelhecimento cutâneo em camundongos sem pelos SKH:hr-1
Beneficiário:Lia Mara Grosso Neves
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 15/24940-8 - Avaliação da eficácia de mudanças estruturais do [10]-gingerol em combinação com o quimioterápico doxorubicina para o tratamento de câncer de mama: estudos in vitro e in vivo
Beneficiário:Márcia Regina Cominetti
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 12/25299-6 - Estudos integrados para o controle de formigas cortadeiras
Beneficiário:João Batista Fernandes
Linha de fomento: Auxílio à Pesquisa - Temático