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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Lycium barbarumpolysaccharide fraction associated with photobiomodulation protects from epithelium thickness and collagen fragmentation in a model of cutaneous photodamage

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Author(s):
Grosso Neves, Lia Mara [1] ; Tim, Carla Roberta [2] ; Floriano, Elaine Medeiros [3] ; da Silva de Avo, Lucimar Retto [4] ; Fernandes, Joao Batista [5] ; Parizotto, Nivaldo Antonio [2, 6, 7] ; Cominetti, Marcia Regina [1]
Total Authors: 7
Affiliation:
[1] Univ Fed Sao Carlos, Dept Gerontol, Lab Biol Aging LABEN, BR-13565905 Sao Carlos, SP - Brazil
[2] Brazil Univ, Postgrad Program Biomed Engn, BR-08230030 Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Dept Pathol & Legal Med, BR-14049900 Ribeirao Preto, SP - Brazil
[4] Univ Fed Sao Carlos, Dept Med, BR-13565905 Sao Carlos, SP - Brazil
[5] Univ Fed Sao Carlos, Dept Chem, BR-13565905 Sao Carlos, SP - Brazil
[6] Univ Fed Sao Carlos, Joint Grad Program Phys Therapy, BR-13565905 Sao Carlos, SP - Brazil
[7] Univ Araraquara, Postgrad Program Biotechnol Regenerat Med & Med C, BR-14801340 Araraquara, SP - Brazil
Total Affiliations: 7
Document type: Journal article
Source: Lasers in Medical Science; v. 36, n. 4 AUG 2020.
Web of Science Citations: 0
Abstract

Ultraviolet radiation (UVR) is the major etiologic agent of cutaneous photoaging, and different strategies are used to prevent and treat this condition. The polysaccharide fraction (LBPF) isolated fromLycium Barbarumfruits (goji berry) contains several active ingredients with antioxidant, immune system modulation, and antitumor effects. In addition, the photobiomodulation (PBM) is widely applied in photoaging treatment. This study investigated the effects of LBPF and PBM against the UVR-induced photodamage in the skin of hairless mice. The mice were photoaged for 6 weeks in a chronic and cumulative exposure regimen using a 300-W incandescent lamp that simulates the UVR effects. From the third to the sixth week of photoaging induction, the animals received topical applications of LBPF and PBM, singly or combined, in different orders (first LBPF and then PBM and inversely), three times per week after each session of photoaging. After completion of experiments, the dorsal region skin was collected for the analysis of thickness, collagen content, and metalloproteinases (MMP) levels. A photoprotective potential against the increase of the epithelium thickness and the fragmentation of the collagen fibers was achieved in the skin of mice treated with LBPF or PBM singly, as well as their combination. All treatments maintained the skin collagen composition, except when PBM was applied after the LBPF. However, no treatment protected against the UVR-induced MMP increase. Taken together, we have shown that the LBPF and PBM promote a photoprotective effect in hairless mice skin against epidermal thickening and low collagen density. Both strategies, singly and combined, can be used to reduce the UVR-induced cutaneous photoaging. (AU)

FAPESP's process: 12/25299-6 - Integrated studies for leaf cutting control
Grantee:João Batista Fernandes
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 13/27021-8 - Effects of the fruit extract of Lycium barbarum L. and red laser in the prevention and treatment of photoaging in hairless mice SKH:hr-1
Grantee:Lia Mara Grosso Neves
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 15/24940-8 - EFFECTIVENESS OF STRUCTURAL CHANGES IN [10]-GINGEROL MOLECULE IN COMBINATION WITH THE CHEMOTHERAPEUTIC DOXORUBICIN FOR THE TREATMENT OF BREAST CANCER: IN VITRO AND IN VIVO STUDIES. ABSTRACT
Grantee:Márcia Regina Cominetti
Support Opportunities: Regular Research Grants