Lipidomics of brown and white adipose tissue: Implications for energy metabolism

Autor(es)

Leiria, Luiz O. ^{[1, 2]} ; Tseng, Yu-Hua ^{[3, 4]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Pharmacol, Ribeirao Preto - Brazil

^[2] Univ Sao Paulo, Ctr Res Inflammatory Dis CRID, Ribeirao Preto Med Sch, Ribeirao Preto, SP - Brazil

^[3] Harvard Med Sch, Joslin Diabet Ctr, Sect Integrat Physiol & Metab, Boston, MA 02115 - USA

^[4] Harvard Univ, Harvard Stem Cell Inst, Cambridge, MA 02138 - USA

• Tipo de documento: Artigo de Revisão
• Fonte: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS; v. 1865, n. 10 OCT 2020.
• Citações Web of Science: 0

Resumo

Adipose tissue exerts multiple vital functions that critically maintain energy balance, including storing and expending energy, as well as secreting factors that systemically modulate nutrient metabolism. Since lipids are the major constituents of the adipocytes, it is unsurprising that the lipid composition of these cells plays a critical role in maintaining their functions and communicating with other organs and cells. In both positive and negative energy balance conditions, lipids and free fatty acids secreted from adipocytes exert either beneficial or detrimental effects in other tissues, such as the liver, pancreas and muscle. The way the adipocytes communicate with other organs tightly depends on the nature of their lipidome composition. Notwithstanding, the lipidome composition of the adipocytes is affected by physiological factors such as adipocyte type, gender and age, but also by environmental cues such as diet composition, thermal stress and physical activity. Here we provide an updated overview on how the adipose tissue lipidome profile is shaped by different physiological and environmental factors and how these changes impact the way the adipocytes regulate whole-body energy metabolism. (AU)

• Processo FAPESP: 17/08264-8 - Estudo dos mecanismos de intercomunicação entre tecido adiposo marrom e fígado com impacto na regulação da lipogênese hepática e produção endógena de glicose
• Beneficiário: Luiz Osório Silveira Leiria
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores