Impact of gestational diabetes on pelvic floor: A prospective cohort study with three-dimensional ultrasound during two-time points in pregnancy

Autor(es):Mostrar menos -

Sartorao Filho, I, Carlos ; Pinheiro, Fabiane A. ^[1] ; Prudencio, Caroline B. ^[1] ; Nunes, Sthefanie K. ^[1] ; Takano, Luiz ^[1] ; Enriquez, Eusebio M. A. ^[1] ; Orlandi, Maiara I. G. ^[1] ; Junginger, Baerbel ^[2] ; Hallur, Raghavendra L. S. ^[1] ; Rudge, Marilza V. C. ^[1] ; Barbosa, Angelica M. P. ^{[1, 3]}

Afiliação do(s) autor(es)

^[1] Sartorao Filho, Carlos, I, Sao Paulo State Univ UNESP, Botucatu Med Sch FMB, Dept Gynecol & Obstet, Botucatu, SP - Brazil

^[2] Charite, Dept Gynecol, Pelv Floor Ctr Charite, Berlin - Germany

^[3] Sao Paulo State Univ UNESP, Sch Philosophy & Sci, Dept Physiotherapy & Occupat Therapy, BR-17525900 Marilia, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: NEUROUROLOGY AND URODYNAMICS; v. 39, n. 8 AUG 2020.
• Citações Web of Science: 0

Resumo

Aim To evaluate the pelvic floor (PF) biometry using three-dimensional ultrasound (US) at two-time points of gestational in pregnant women with gestational diabetes mellitus (GDM). Methods A prospective cohort study conducted at the Perinatal Diabetes Research Center including 44 pregnant women with GDM and 66 pregnant women without GDM at 24 to 28 weeks of gestation. Three-dimensional transperineal US was performed at 24 to 28 and 34 to 38 weeks of gestation in the lithotomy position at rest. The axial plane of the minimal Levator hiatal dimensions was used to determine Levator ani muscle and Hiatal area (HA) biometry at 24 to 28 and 34 to 38 weeks of gestation. Results Of the 110 pregnant women, 100 (90.9%) completed the follow-up at 34 to 38 weeks of gestation. The evaluation by US showed a negative biometric change between the two-time points, during pregnancy in women with GDM; in the HA (beta coefficient: estimative of effect in biometric progression according to GDM diagnosis, using the non-GDM group as reference = -6.76;P = .020), anteroposterior diameter (beta = -5.07;P = .019), and Levator ani thickness (beta = -12.34;P = .005). Conclusions Pregnant women with GDM had a significantly lower than expected percentage of changes in biometry of Levator ani thickness and HA from 24 to 28 to 34 to 38 weeks of gestation when compared with the group of pregnant women without GDM. GDM alters the morphology of PF structures assessed by three-dimension US. This reported complication may be implicated in adverse birth outcomes and may play a role in the development of PF dysfunction. (AU)

• Processo FAPESP: 16/01743-5 - Coorte da tríade gestacional: hiperglicemia, incontinência urinária e perfil clínico, molecular e ômico da miopatia hiperglicêmica na predição de incontinência e disfunção muscular e pesquisa translacional com biodevice para regeneração muscular em ratas
• Beneficiário: Marilza Vieira Cunha Rudge
• Modalidade de apoio: Auxílio à Pesquisa - Temático