Phytochemical analysis of the methanolic leaves extract of Niedenzuella multiglandulosa (Malpighiaceae), a plant species toxic to cattle in Brazil

Autor(es)

Russo, Helena Mannochio ^[1] ; Queiroz, Emerson Ferreira ^[2] ; Marcourt, Laurence ^[2] ; Rutz, Adriano ^[2] ; Allard, Pierre -Marie ^[2] ; Almeida, Rafael Felipe de ^[3] ; Carvalho, Nilton Marques ^[4] ; Wolfender, Jean-Luc ^[2] ; Bolzani, Vanderlan da Silva ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ UNESP, Inst Chem, Dept Organ Chem, Nucleus Bioassays Biosynth & Ecophysiol Nat Prod, BR-14800900 Araraquara, SP - Brazil

^[2] Univ Lausanne, Univ Geneva, Sch Pharmaceut Sci, 1 Rue Michel Servet, CH-1211 Geneva 4 - Switzerland

^[3] Fed Univ Minas Gerais UFMG, Inst Biol Sci, Dept Bot, BR-31270901 Belo Horizonte, MG - Brazil

^[4] Feredal Univ Mato Grosso Sul UFMS, Fac Vet Med & Zootech FAMEZ, BR-79070900 Campo Grande, MS - Brazil

• Tipo de documento: Artigo Científico
• Fonte: PHYTOCHEMISTRY LETTERS; v. 37, p. 10-16, JUN 2020.
• Citações Web of Science: 2

Resumo

Niedenzuella multiglandulosa (Malpighiaceae) is a neotropical liana responsible for cattle intoxication outbreaks in Brazil that may lead to abortion and even death of the animals, causing substantial losses in Brazilian trade balance. A phytochemical study of N. multiglandulosa leaves was performed in order to obtain chemical information about secondary metabolites of this poorly studied species. The methanolic extract was purified by medium pressure liquid chromatography (MPLC) combined with semi preparative HPLC-PDA leading to the isolation of 16 compounds, including a new steroid named 5-hydroxypodecdysone B (13). The structure of the isolated compounds was determined by classical spectroscopic methods such as NMR and HRMS. Complementary F-19 NMR and UPLC-HRMS analysis did not detect the presence of monofluoracetate (MFA), a toxic compound previously described from this species. (AU)

• Processo FAPESP: 16/16970-7 - Estudo do impacto da função de eIF5A no perfil proteômico celular utilizando o modelo de Saccharomyces cerevisiae
• Beneficiário: Cleslei Fernando Zanelli
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 14/50926-0 - INCT 2014: biodiversidade e produtos naturais
• Beneficiário: Vanderlan da Silva Bolzani
• Modalidade de apoio: Auxílio à Pesquisa - Programa BIOTA - Temático