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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Phytochemical analysis of the methanolic leaves extract of Niedenzuella multiglandulosa (Malpighiaceae), a plant species toxic to cattle in Brazil

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Author(s):
Russo, Helena Mannochio [1] ; Queiroz, Emerson Ferreira [2] ; Marcourt, Laurence [2] ; Rutz, Adriano [2] ; Allard, Pierre -Marie [2] ; Almeida, Rafael Felipe de [3] ; Carvalho, Nilton Marques [4] ; Wolfender, Jean-Luc [2] ; Bolzani, Vanderlan da Silva [1]
Total Authors: 9
Affiliation:
[1] Sao Paulo State Univ UNESP, Inst Chem, Dept Organ Chem, Nucleus Bioassays Biosynth & Ecophysiol Nat Prod, BR-14800900 Araraquara, SP - Brazil
[2] Univ Lausanne, Univ Geneva, Sch Pharmaceut Sci, 1 Rue Michel Servet, CH-1211 Geneva 4 - Switzerland
[3] Fed Univ Minas Gerais UFMG, Inst Biol Sci, Dept Bot, BR-31270901 Belo Horizonte, MG - Brazil
[4] Feredal Univ Mato Grosso Sul UFMS, Fac Vet Med & Zootech FAMEZ, BR-79070900 Campo Grande, MS - Brazil
Total Affiliations: 4
Document type: Journal article
Source: PHYTOCHEMISTRY LETTERS; v. 37, p. 10-16, JUN 2020.
Web of Science Citations: 2
Abstract

Niedenzuella multiglandulosa (Malpighiaceae) is a neotropical liana responsible for cattle intoxication outbreaks in Brazil that may lead to abortion and even death of the animals, causing substantial losses in Brazilian trade balance. A phytochemical study of N. multiglandulosa leaves was performed in order to obtain chemical information about secondary metabolites of this poorly studied species. The methanolic extract was purified by medium pressure liquid chromatography (MPLC) combined with semi preparative HPLC-PDA leading to the isolation of 16 compounds, including a new steroid named 5-hydroxypodecdysone B (13). The structure of the isolated compounds was determined by classical spectroscopic methods such as NMR and HRMS. Complementary F-19 NMR and UPLC-HRMS analysis did not detect the presence of monofluoracetate (MFA), a toxic compound previously described from this species. (AU)

FAPESP's process: 16/16970-7 - Study of the impact of the role of eIF5A in the cell proteomic profile using Saccharomyces cerevisiae as a model
Grantee:Cleslei Fernando Zanelli
Support Opportunities: Regular Research Grants
FAPESP's process: 14/50926-0 - INCT 2014: biodiversity and natural products
Grantee:Vanderlan da Silva Bolzani
Support Opportunities: BIOTA-FAPESP Program - Thematic Grants