Cytotoxic sesquiterpene lactones from Campuloclinium macrocephalum (=Eupatorium macrocephalum)

Autor(es)

Pereira Cabral, Marcia R. ^[1] ; Cecchetto, Mariana ^[2] ; Batista, Jr., Joao M. ^[3] ; Batista, Andrea N. L. ^[4] ; Foglio, Mary Ann ^[2] ; Tasca Gois Ruiz, Ana Lucia ^[2] ; Barrotto do Carmo, Marta R. ^[5] ; da Costa, Willian Ferreira ^[1] ; Baldoqui, Debora C. ^[1] ; Sarragiotto, Maria H. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Maringa, Dept Quim, Av Colombo 5790, BR-87020900 Maringa, Parana - Brazil

^[2] Univ Estadual Campinas, Fac Ciencias Farmaceut, R Candido Portinari 200, Cidade Univ, BR-13083871 Campinas, SP - Brazil

^[3] Univ Fed Sao Paulo, Inst Ciencia & Tecnol, R Talim 330, BR-12231280 Sao Jose Dos Campos, SP - Brazil

^[4] Univ Fed Fluminense, Inst Quim, Outeiro De Sao Joao Batista S-N, BR-24020141 Niteroi, RJ - Brazil

^[5] Univ Estadual Ponta Grossa, Dept Biol Geral, Av Carlos Cavalcanti 4748, BR-84030910 Ponta Grossa, Parana - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Phytochemistry; v. 179, NOV 2020.
• Citações Web of Science: 0

Resumo

Three undescribed germacranolide sesquiterpene lactones, named macrocephalides A-C, along with known steroids, triterpenes and flavonoids were isolated from the aerial parts of Campuloclinium macrocephalum. The structures of the undescribed compounds were elucidated with basis on their 1D and 2D-NMR, and HR-ESI-MS data. Their absolute configurations were assigned by comparison of experimental and calculated electronic circular dichroism (ECD) spectra. Additionally, macmcephalides A-C were evaluated for their in vitro cytotoxic activities against nine human cancer cell lines. Macmcephalides A and B exhibited moderate to potent cytotoxic activity, inhibiting 50% of cell growth (GI(50)) at concentrations ranging from 0.576 to 6.37 mu M. (AU)

• Processo FAPESP: 14/25222-9 - Espectroscopia quiróptica vibracional na caracterização estereoquímica de pequenas moléculas e macromoléculas
• Beneficiário: João Marcos Batista Junior
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores