Evaluation of acrylic acid grafting on the loading and release of scopolamine butylbromide from polymeric matrices for future sialorrhea treatment

Autor(es)

Morise, Beatriz Tiemi ^{[1, 2]} ; Mutch, Alexandra Louise ^[2] ; Garms, Bruna Cambraia ^[2] ; Herculano, Rondinelli Donizetti ^[1] ; Grondahl, Lisbeth ^{[2, 3]}

Afiliação do(s) autor(es)

^[1] S ao Paulo State Univ, Sch Pharmaceut Sci, Araraquara, SP - Brazil

^[2] Univ Queensland, Sch Chem & Mol Biosci, Cooper Rd, Brisbane, Qld 4072 - Australia

^[3] Univ Queensland, Australian Inst Bioengn & Nanotechnol, Brisbane, Qld - Australia

• Tipo de documento: Artigo Científico
• Fonte: Journal of Applied Polymer Science; v. 138, n. 13 NOV 2020.
• Citações Web of Science: 0

Resumo

Sialorrhea is a disorder which causes an increase in salivation. Scopolamine butylbromide (SBB) can be administrated to treat sialorrhea and its transdermal application minimizes the occurrence of side effects. This work compared SBB adsorption and release from two polymer matrices, polycaprolactone and natural rubber latex, as well as the matrices modified by gamma irradiation-induced graft copolymerization of acrylic acid (AAc). Grafting with AAc-introduced carboxylate groups onto the surface of the matrices evident from chemical analysis and resulted in increased hydrophilicity evident from contact angle measurements. SBB adsorbed to the matrices without changing its structure and for the AAc-grafted matrices this was governed by electrostatic interactions. Higher SBB loading was observed for the AAc-grafted matrices while SBB release was slower for the non-grafted matrices than the grafted matrices. The four different matrices produced are candidates for the development of a transdermal drug delivery system. (AU)

• Processo FAPESP: 17/22686-2 - Desenvolvimento e caracterização físico, química e biológica das membranas de látex carreadas com escopolamina para tratamento da Sialorréia
• Beneficiário: Beatriz Tiemi Morise
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 19/01650-5 - Desenvolvimento e caracterização de matrizes de policaprolactona e membranas de látex natural modificadas por radiação gama carreadas com escopolamina para tratamento da sialorréia
• Beneficiário: Beatriz Tiemi Morise
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Iniciação Científica