| Texto completo | |
| Autor(es): |
Schuch, Lauren F.
[1]
;
Silveira, Felipe M.
[1]
;
Wagner, Vivian P.
[1]
;
Borgato, Gabriell B.
[1]
;
Rocha, Guilherme Z.
[1]
;
Castilho, Rogerio M.
[2, 3]
;
Vargas, Pablo A.
[1]
;
Martins, Manoela D.
[1, 4]
Número total de Autores: 8
|
| Afiliação do(s) autor(es): | [1] Univ Estadual Campinas, Piracicaba Dent Sch, Dept Oral Diag, Piracicaba, SP - Brazil
[2] Univ Michigan, Sch Dent, Lab Epithelial Biol, Dept Periodont & Oral Med, Ann Arbor, MI 48109 - USA
[3] Univ Michigan, Comprehens Canc Ctr, Ann Arbor, MI 48109 - USA
[4] Univ Fed Rio Grande do Sul, Sch Dent, Dept Oral Pathol, Porto Alegre, RS - Brazil
Número total de Afiliações: 4
|
| Tipo de documento: | Artigo de Revisão |
| Fonte: | CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY; v. 155, NOV 2020. |
| Citações Web of Science: | 0 |
| Resumo | |
Background: Patient-derived xenograft (PDX) involve the direct surgical transfer of fresh human tumor samples to immunodeficient mice. This systematic review aimed to identify publications of head and neck cancer PDX (HNC-PDX) models, describing the main methodological characteristics and outcomes. Methods: An electronic search was undertaken in four databases, including publications having used HNC-PDX. Data were analyzed descriptively. Results: 63 articles were yielded. The nude mouse was one most commonly animal model used (38.8 %), and squamous cell carcinoma accounted for the majority of HNC-PDX (80.6 %). Tumors were mostly implanted in the flank (86.3 %), and the latency period ranged from 30 to 401 days. The successful rate ranged from 17 % to 100 %. Different drugs and pathways were identified. Conclusion: HNC-PDX appears to significantly recapitulate the morphology of the original HNC and represents a valuable method in translational research for the assessment of the in vivo effect of novel therapies for HNC. (AU) | |
| Processo FAPESP: | 16/21785-4 - Relação da via de sinalização BDNF/TRKB com a agressividade e perfil de células tronco tumorais de neoplasias malignas de glândula salivar |
| Beneficiário: | Vivian Petersen Wagner |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |