Two polyphenol-rich Brazilian fruit extracts protect from diet-induced obesity and hepatic steatosis in mice

Autor(es)

Ballard, Cintia Reis ^[1] ; dos Santos, Elisvania Freitas ^[2] ; Dubois, Marie-Julie ^[3] ; Pilon, Genevieve ^[3] ; Betim Cazarin, Cinthia Bau ^[1] ; Marostica Junior, Mario Roberto ^[1] ; Marette, Andre ^[3]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Sch Food Engn, Dept Food & Nutr, 80 Monteiro Lobato, BR-13083862 Campinas, SP - Brazil

^[2] Univ Fed Mato Grosso do Sul, Sch Pharmaceut Sci Food & Nutr, S-N Costa & Silva, BR-79070900 Campo Grande, MS - Brazil

^[3] Laval Univ, Laval Hosp, Quebec Heart & Lung Inst, 2725 St Foy, Quebec City, PQ G1V 4G5 - Canada

• Tipo de documento: Artigo Científico
• Fonte: FOOD & FUNCTION; v. 11, n. 10, p. 8800-8810, OCT 1 2020.
• Citações Web of Science: 0

Resumo

Consumption of polyphenol-rich food is associated with better metabolic health. Tucum-do-Pantanal (Bactris setosa Mart) and taruma-do-cerrado (Vitex cymosa Bertero ex Spreng) are underexploited native Brazilian fruits with an important source of phytochemicals. In this study, we assessed the effects of 100 mg kg(-1)tucum (TPE) and taruma (TCE) extracts on diet-induced obesity (DIO) C57BL/6J mice. After 8 weeks of daily treatment, TPE and TCE were found to significantly prevented the diet-induced body weight gain and fully protected against hepatic steatosis associated with a tendency to stimulate hepatic AMPK phosphorylation. TPE reduced visceral obesity and improved glucose metabolism as revealed by an improvement of the insulin tolerance test, a reduction in the insulin fasting level, and a decreased glucose-induced hyperinsulinemia during an oral glucose tolerance test. TPE and TCE showed promising effects on the treatment of obesity and NAFLD, furthermore, TPE on insulin resistance. (AU)

• Processo FAPESP: 15/50333-1 - Cobra: nova plataforma de descoberta de compostos para identificação rápida e de baixo custo de bioativo com efeitos benéficos originários de plantas brasileiras
• Beneficiário: Glaucia Maria Pastore
• Modalidade de apoio: Auxílio à Pesquisa - Temático