Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

B chromosomes of multiple species have intense evolutionary dynamics and accumulated genes related to important biological processes

Texto completo
Autor(es):
Ahmad, Syed F. [1] ; Jehangir, Maryam [1] ; Cardoso, Adauto L. [1] ; Wolf, Ivan R. [1] ; Margarido, Vladimir P. [2] ; Cabral-de-Mello, Diogo C. [3] ; O'Neill, Rachel [4, 5] ; Valente, Guilherme T. [6] ; Martins, Cesar [1]
Número total de Autores: 9
Afiliação do(s) autor(es):
[1] Sao Paulo State Univ UNESP, Inst Biosci Botucatu, Dept Struct & Funct Biol, BR-18618689 Botucatu, SP - Brazil
[2] Western Parana State Univ UNIOESTE, Ctr Biol Sci & Hlth, Cascavel, PR - Brazil
[3] Sao Paulo State Univ UNESP, Inst Biosci, Dept Gen & Appl Biol, Rio Claro, SP - Brazil
[4] Univ Connecticut UCONN, Dept Mol & Cell Biol, Storrs, CT - USA
[5] Univ Connecticut UCONN, Inst Syst Genom, Storrs, CT - USA
[6] Sao Paulo State Univ UNESP, Agron Sci Fac, Bioproc & Biotechnol Dept, Botucatu, SP - Brazil
Número total de Afiliações: 6
Tipo de documento: Artigo Científico
Fonte: BMC Genomics; v. 21, n. 1 SEP 23 2020.
Citações Web of Science: 0
Resumo

BackgroundOne of the biggest challenges in chromosome biology is to understand the occurrence and complex genetics of the extra, non-essential karyotype elements, commonly known as supernumerary or B chromosomes (Bs). The non-Mendelian inheritance and non-pairing abilities of B chromosomes make them an interesting model for genomics studies, thus bringing to bear different questions about their genetic composition, evolutionary survival, maintenance and functional role inside the cell. This study uncovers these phenomena in multiple species that we considered as representative organisms of both vertebrate and invertebrate models for B chromosome analysis.ResultsWe sequenced the genomes of three animal species including two fishes Astyanax mexicanus and Astyanax correntinus, and a grasshopper Abracris flavolineata, each with and without Bs, and identified their B-localized genes and repeat contents. We detected unique sequences occurring exclusively on Bs and discovered various evolutionary patterns of genomic rearrangements associated to Bs. In situ hybridization and quantitative polymerase chain reactions further validated our genomic approach confirming detection of sequences on Bs. The functional annotation of B sequences showed that the B chromosome comprises regions of gene fragments, novel genes, and intact genes, which encode a diverse set of functions related to important biological processes such as metabolism, morphogenesis, reproduction, transposition, recombination, cell cycle and chromosomes functions which might be important for their evolutionary success.ConclusionsThis study reveals the genomic structure, composition and function of Bs, which provide new insights for theories of B chromosome evolution. The selfish behavior of Bs seems to be favored by gained genes/sequences. (AU)

Processo FAPESP: 18/03877-4 - Exploração de dados de sequenciamento de nova geração para descobrir o conteúdo genômico e origem dos cromossomos B.
Beneficiário:Syed Farhan Ahmad
Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado
Processo FAPESP: 15/16661-1 - Cromossomos sexuais, cromossomos B e seus enigmas: sistemas modelo para estudos de evolução cromossômica e genômica
Beneficiário:César Martins
Modalidade de apoio: Auxílio à Pesquisa - Temático
Processo FAPESP: 14/16477-3 - Análise genômica em larga escala aplicadas à biologia de Cromossomos B
Beneficiário:Syed Farhan Ahmad
Modalidade de apoio: Bolsas no Brasil - Doutorado