Intracellular PRRs Activation in Targeting the Immune Response Against Fungal Infections

Autor(es)

Jannuzzi, Grasielle Pereira ^[1] ; de Almeida, Jose Roberto Fogaca ^[1] ; Paulo, Larissa Neves Monteiro ^[1] ; de Almeida, Sandro Rogerio ^[1] ; Ferreira, Karen Spadari ^[2]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Anal Clin, Fac Ciencias Farmaceut, Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo, Dept Ciencias Biol, Inst Ciencias Ambientais Quim & Farmaceut, Diadema - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY; v. 10, OCT 20 2020.
• Citações Web of Science: 1

Resumo

The immune response against fungal infections is complex and exhibits several factors involving innate elements that participate in the interaction with the fungus. The innate immune system developed pattern recognition receptors that recognize different pathogen-associated molecular patterns present both on the surface of the fungi cell wall and on their genetic material. These receptors have the function of activating the innate immune response and regulating a subsequent adaptive immune response. Among pattern recognition receptors, the family of Toll-like receptors and C-type lectin receptors are the best described and characterized, they act directly in the recognition of pathogen-associated molecular patterns expressed on the wall of the fungus and consequently in directing the immune response. In recent years, the role of intracellular pattern recognition receptors (TLR3, TLR7, TLR8, and TLR9) has become increasingly important in the pathophysiology of some mycoses, as paracoccidioidomycosis, cryptococcosis, aspergillosis, and candidiasis. The recognition of nucleic acids performed by these receptors can be essential for the control of some fungal infections, as they can be harmful to others. Therefore, this review focuses on highlighting the role played by intracellular pattern recognition receptors both in controlling the infection and in the host's susceptibility against the main fungi of medical relevance. (AU)

• Processo FAPESP: 18/07073-7 - Determinação dos mecanismos inatos e adaptativos no reconhecimento do Sporothrix brasiliensis por macrófagos e células dendríticas
• Beneficiário: Grasielle Pereira Jannuzzi
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado