Nontraditional Application of the Photo-Fenton Process: A Novel Strategy for Molecular Construction Using Formamide and Flow Chemistry

Autor(es)

Sanabria, Marialy N. ^[1] ; Hornink, Milene M. ^[1] ; Correia, Valquiria G. ^[1] ; Andrade, Leandro H. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Chem, BR-05300080 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ORGANIC PROCESS RESEARCH & DEVELOPMENT; v. 24, n. 10, p. 2288-2297, OCT 16 2020.
• Citações Web of Science: 1

Resumo

Instead of destroying organic compounds, for the first time the photo-Fenton reaction was employed to construct them. Oxindole and spiro-oxindole scaffolds, which are frequently found in natural products, were selected as molecular targets. The development of a photochemical flow reactor employing the photo-Fenton reaction in formamide resulted in an excellent synthetic methodology for oxindoles. Non-anhydrous conditions are required, and readily available chemicals and mild conditions are employed. Also, novel synthetic approaches for new spiro compounds were efficiently developed using functionalized oxindoles as key intermediates. (AU)

• Processo FAPESP: 19/10762-1 - Desenvolvimento de uma plataforma sintética envolvendo radicais carbamoíla: aplicação da formamida na síntese de compostos heterocíclicos
• Beneficiário: Leandro Helgueira de Andrade
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 17/02854-8 - Estudo visando a geração e aplicação sintética de radicais carbamoila via fotocatálise
• Beneficiário: Leandro Helgueira de Andrade
• Modalidade de apoio: Auxílio à Pesquisa - Regular