| Full text | |
| Author(s): |
Sanabria, Marialy N.
[1]
;
Hornink, Milene M.
[1]
;
Correia, Valquiria G.
[1]
;
Andrade, Leandro H.
[1]
Total Authors: 4
|
| Affiliation: | [1] Univ Sao Paulo, Inst Chem, BR-05300080 Sao Paulo, SP - Brazil
Total Affiliations: 1
|
| Document type: | Journal article |
| Source: | ORGANIC PROCESS RESEARCH & DEVELOPMENT; v. 24, n. 10, p. 2288-2297, OCT 16 2020. |
| Web of Science Citations: | 1 |
| Abstract | |
Instead of destroying organic compounds, for the first time the photo-Fenton reaction was employed to construct them. Oxindole and spiro-oxindole scaffolds, which are frequently found in natural products, were selected as molecular targets. The development of a photochemical flow reactor employing the photo-Fenton reaction in formamide resulted in an excellent synthetic methodology for oxindoles. Non-anhydrous conditions are required, and readily available chemicals and mild conditions are employed. Also, novel synthetic approaches for new spiro compounds were efficiently developed using functionalized oxindoles as key intermediates. (AU) | |
| FAPESP's process: | 19/10762-1 - Development of a synthetic platform using carbamoyl radicals: application of the formamide in the synthesis of heterocyclic compounds |
| Grantee: | Leandro Helgueira de Andrade |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 17/02854-8 - Synthetic applications of carbamoyl radicals via photocatalysis |
| Grantee: | Leandro Helgueira de Andrade |
| Support Opportunities: | Regular Research Grants |