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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Nontraditional Application of the Photo-Fenton Process: A Novel Strategy for Molecular Construction Using Formamide and Flow Chemistry

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Author(s):
Sanabria, Marialy N. [1] ; Hornink, Milene M. [1] ; Correia, Valquiria G. [1] ; Andrade, Leandro H. [1]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Inst Chem, BR-05300080 Sao Paulo, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: ORGANIC PROCESS RESEARCH & DEVELOPMENT; v. 24, n. 10, p. 2288-2297, OCT 16 2020.
Web of Science Citations: 1
Abstract

Instead of destroying organic compounds, for the first time the photo-Fenton reaction was employed to construct them. Oxindole and spiro-oxindole scaffolds, which are frequently found in natural products, were selected as molecular targets. The development of a photochemical flow reactor employing the photo-Fenton reaction in formamide resulted in an excellent synthetic methodology for oxindoles. Non-anhydrous conditions are required, and readily available chemicals and mild conditions are employed. Also, novel synthetic approaches for new spiro compounds were efficiently developed using functionalized oxindoles as key intermediates. (AU)

FAPESP's process: 19/10762-1 - Development of a synthetic platform using carbamoyl radicals: application of the formamide in the synthesis of heterocyclic compounds
Grantee:Leandro Helgueira de Andrade
Support Opportunities: Regular Research Grants
FAPESP's process: 17/02854-8 - Synthetic applications of carbamoyl radicals via photocatalysis
Grantee:Leandro Helgueira de Andrade
Support Opportunities: Regular Research Grants