| Texto completo | |
| Autor(es): |
Alexandre, Pamela A.
[1, 2]
;
Reverter, Antonio
[2]
;
Berezin, Roberta B.
[1]
;
Porto-Neto, Laercio R.
[2]
;
Ribeiro, Gabriela
[1]
;
Santana, Miguel H. A.
[3]
;
Ferraz, Jose Bento S.
[1]
;
Fukumasu, Heidge
[1]
Número total de Autores: 8
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Fac Anim Sci & Food Engn, Dept Vet Med, BR-13635900 Pirassununga, SP - Brazil
[2] CSIRO, Agr & Food, Brisbane, Qld 4067 - Australia
[3] Univ Sao Paulo, Fac Anim Sci & Food Engn, Dept Anim Sci, BR-13635900 Pirassununga, SP - Brazil
Número total de Afiliações: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | GENES; v. 11, n. 9 SEP 2020. |
| Citações Web of Science: | 1 |
| Resumo | |
Long non-coding RNA (lncRNA) can regulate several aspects of gene expression, being associated with complex phenotypes in humans and livestock species. In taurine beef cattle, recent evidence points to the involvement of lncRNA in feed efficiency (FE), a proxy for increased productivity and sustainability. Here, we hypothesized specific regulatory roles of lncRNA in FE of indicine cattle. Using RNA-Seq data from the liver, muscle, hypothalamus, pituitary gland and adrenal gland from Nellore bulls with divergent FE, we submitted new transcripts to a series of filters to confidently predict lncRNA. Then, we identified lncRNA that were differentially expressed (DE) and/or key regulators of FE. Finally, we explored lncRNA genomic location and interactions with miRNA and mRNA to infer potential function. We were able to identify 126 relevant lncRNA for FE inBos indicus, some with high homology to previously identified lncRNA inBos taurusand some possible specific regulators of FE in indicine cattle. Moreover, lncRNA identified here were linked to previously described mechanisms related to FE in hypothalamus-pituitary-adrenal axis and are expected to help elucidate this complex phenotype. This study contributes to expanding the catalogue of lncRNA, particularly in indicine cattle, and identifies candidates for further studies in animal selection and management. (AU) | |
| Processo FAPESP: | 17/14707-0 - Análises ômicas multi-teciduais para caracterizar a eficiência alimentar em bovinos de corte |
| Beneficiário: | Pâmela Almeida Alexandre |
| Modalidade de apoio: | Bolsas no Exterior - Estágio de Pesquisa - Doutorado |
| Processo FAPESP: | 15/22276-3 - Abordagem de Biologia de Sistemas Para a Determinação de Mecanismos Moleculares Associados à Eficiência Alimentar de Bovinos Nelore |
| Beneficiário: | Pâmela Almeida Alexandre |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 14/07566-2 - Genômica aplicada à produção de ruminantes |
| Beneficiário: | José Bento Sterman Ferraz |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |