Natural Self-Ligand Gamma Delta T Cell Receptors (gamma delta TCRs) Insight: The Potential of Induced IgG

Autor(es)

de Sousa, Thamires Rodrigues ^[1] ; Victor, Jefferson Russo ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Med Sch, Div Clin Dermatol, Lab Med Invest LIM 56, BR-05403000 Sao Paulo - Brazil

^[2] Laureate Int Univ, FMU, Div Environm Hlth, BR-04505002 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: VACCINES; v. 8, n. 3 SEP 2020.
• Citações Web of Science: 0

Resumo

A gamma delta T cell acquires functional properties in response to the gamma delta T cell receptor gamma delta TCR signal strength during its development in the thymus. The elucidation of the potential ligands of gamma delta T cell receptors are of extreme importance; however, they are still not understood. Here we revise the actual state of the art of candidates to exert the function of gamma delta TCR ligands, and propose a theoretical contribution about new potential ligands of gamma delta TCRs, based on biological and hypothetical pieces of evidence in the literature. In conclusion, we hypothetically suggest a possible role of induced antibodies according to the individual's immune status, mainly of the IgG subclass, acting as gamma delta TCR ligands. Considering that IgG production is involved in some essential immunotherapy protocols, and almost all vaccination protocols, our discussion opens a new and broad field to further exploration. (AU)

• Processo FAPESP: 19/09741-0 - Análise do efeito modulador dos anticorpos IgG de indivíduos atópicos ao ácaro Dermatophagoides pteronyssiunus na maturação e produção de citocinas de linfócitos intratímicos humanos
• Beneficiário: Thamires Rodrigues de Sousa
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 18/05181-7 - Avaliação translacional do efeito modulador e/ou regulador dos anticorpos IgG na maturação de linfócitos TCD4, TCD8, nTreg, Tgammadelta e B intra-tímicos de neonatos.
• Beneficiário: Alberto José da Silva Duarte
• Modalidade de apoio: Auxílio à Pesquisa - Regular