Ibuprofen compromises sexual behavior and fertility in female rats exposed during the perinatal period

Autor(es)

Jorge, Barbara Campos ^[1] ; Balin, Paola da Silva ^[1] ; Carneiro, Giovanna de Brito ^[1] ; Belleti, Rafael ^[1] ; Casali Reis, Ana Carolina ^[1] ; Stein, Julia ^[1] ; de Barros, Aline Lima ^[2] ; Leite Kassuya, Candida Aparecida ^[3] ; Arena, Arielle Cristina ^{[1, 4]}

Afiliação do(s) autor(es)

^[1] Univ Estadual Paulista Botucatu, UNESP, Inst Biosci Botucatu, Dept Struct & Funct Biol, Dist Rubiao Jr S-N, BR-18618970 Sao Paulo - Brazil

^[2] Univ Estadual Mato Grosso do Sul UEMS, Campo Grande, MS - Brazil

^[3] Fed Univ Grande Dourados, Coll Hlth Sci, Dourados, MS - Brazil

^[4] Univ Estadual Paulista Botucatu, UNESP, Ctr Toxicol Assistance CEATOX, Inst Biosci Botucatu, Botucatu, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY; v. 102, n. 9, p. 490-505, 2020.
• Citações Web of Science: 0

Resumo

The influence of ibuprofen exposure during the perinatal period, when the brain sexual differentiation process occurs, on the sexual behavior and fertility of female offspring Wistar rats has been evaluated. Ibuprofen was orally administered to the dams at doses of 0, 10, 30 or 60 mg/kg during the gestational (from day 15 to delivery) and lactational period. Females exposed to ibuprofen showed no signs of maternal toxicity. However, ibuprofen provoked a reduction in intrauterine and postnatal growth in female offspring. The treated offspring also showed a decrease in the anogenital distance at birth, while no difference was observed in external signs of the onset of puberty. At adulthood, although the ibuprofen did not interfere with the estrous cyclicity, the lordosis quotient of treated females was reduced. Furthermore, these females presented reduced fertility and low fetal and placenta weights. The females also presented an increase in the percentage of small fetuses and a reduction in the large fetuses for their gestational ages. Perinatal exposure to ibuprofen may interfere with the sexual differentiation of the brain of female offspring of Wistar rats, causing a long-term impact in the sexual behavior and fertility of these females. (AU)

• Processo FAPESP: 17/03997-7 - Influência da exposição in útero e lactacional ao anti-inflamatório ibuprofeno: repercussão tardia em parâmetros reprodutivos masculinos, em ratos
• Beneficiário: Andressa Rejani Ribeiro Leite
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 16/12110-3 - Parâmetros reprodutivos masculinos de ratos expostos perinatalmente ao anti-inflamatório Ibuprofeno: aspectos morfológicos, seminais, comportamentais e moleculares.
• Beneficiário: Arielle Cristina Arena
• Modalidade de apoio: Auxílio à Pesquisa - Regular