Unpuzzling COVID-19: tissue-related signaling pathways associated with SARS-CoV-2 infection and transmission

Autor(es)

Battagello, Daniella S. ^[1] ; Dragunas, Guilherme ^[2] ; Klein, Marianne O. ^[1] ; Ayub, Ana L. P. ^[3] ; Velloso, Fernando J. ^[4] ; Correa, Ricardo G. ^[5]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Biomed Sci, Dept Anat, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Inst Biomed Sci, Dept Pharmacol, Sao Paulo - Brazil

^[3] Fed Univ Sao Paulo UNIFESP, Dept Pharmacol, Sao Paulo - Brazil

^[4] Rutgers NJMS, Dept Pharmacol Physiol & Neurosci, Newark, NJ - USA

^[5] Sanford Burnham Prebys SBP Med Discovery Inst, NCI Designated Canc Ctr, La Jolla, CA 92037 - USA

• Tipo de documento: Artigo de Revisão
• Fonte: Clinical Science; v. 134, n. 16, p. 2137-2160, AUG 2020.
• Citações Web of Science: 2

Resumo

The highly infective coronavirus disease 19 (COVID-19) is caused by a novel strain of coronaviruses - the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) - discovered in December 2019 in the city of Wuhan (Hubei Province, China). Remarkably, COVID-19 has rapidly spread across all continents and turned into a public health emergency, which was ultimately declared as a pandemic by the World Health Organization (WHO) in early 2020. SARS-CoV-2 presents similar aspects to other members of the coronavirus family, mainly regarding its genome, protein structure and intracellular mechanisms, that may translate into mild (or even asymptomatic) to severe infectious conditions. Although the mechanistic features underlying the COVID-19 progression have not been fully clarified, current evidence have suggested that SARS-CoV-2 may primarily behave as other beta-coronavirus members. To better understand the development and transmission of COVID-19, unveiling the signaling pathways that may be impacted by SARS-CoV-2 infection, at the molecular and cellular levels, is of crucial importance. In this review, we present the main aspects related to the origin, classification, etiology and clinical impact of SARS-CoV-2. Specifically, here we describe the potential mechanisms of cellular interaction and signaling pathways, elicited by functional receptors, in major targeted tissues/organs from the respiratory, gastrointestinal (GI), cardiovascular, renal, and nervous systems. Furthermore, the potential involvement of these signaling pathways in evoking the onset and progression of COVID-19 symptoms in these organ systems are presently discussed. A brief description of future perspectives related to potential COVID-19 treatments is also highlighted. (AU)

• Processo FAPESP: 17/17998-5 - Avaliação dos efeitos da administração crônica do hormônio concentrador de melanina (MCH) em ratas Long-Evans lactantes
• Beneficiário: Marianne Orlandini Klein
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 17/16549-2 - Estressando as vias aéreas: plasticidade neuronal na inflamação pulmonar alérgica
• Beneficiário: Guilherme Dragunas
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 19/05641-0 - Papel de lncRNAs e de redes regulatórias envolvendo lncRNAs, miRNAs e mRNAs na progressão do Melanoma
• Beneficiário: Ana Luisa Pedroso Ayub
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto