Association between exposure to air pollution during intrauterine life and cephalic circumference of the newborn

Autor(es)

Carvalho, Mariana Azevedo ^[1] ; Hettfleisch, Karen ^[1] ; Rodrigues, Agatha S. ^{[2, 1]} ; Benachi, Alexandra ^[3] ; Vieira, Sandra Elisabete ^[4] ; Saldiva, Silvia R. D. M. ^[5] ; Saldiva, Paulo Hilario N. ^[6] ; Francisco, Rossana Pulcineli Vieira ^[1] ; Bernardes, Lisandra Stein ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Med Sch, Dept Obstet & Gynecol, 255 Av Dr Eneas Carvalho Aguiar, BR-05403900 Sao Paulo - Brazil

^[2] Univ Fed Espirito Santo, Dept Stat, Vitoria, ES - Brazil

^[3] Antoine Beclere Hosp, AP HP, Dept Ob GYN & Reprod Med, F-92141 Clamart - France

^[4] Univ Sao Paulo, Med Sch, Dept Pediat, 255 Av Dr Eneas Carvalho Aguiar, BR-05403900 Sao Paulo - Brazil

^[5] State Hlth Secretariat, Hlth Inst, 590 Rua Santo Antonio, BR-01314000 Sao Paulo - Brazil

^[6] Univ Sao Paulo, Inst Adv Studies, 455 Av Dr Arnaldo, BR-01246903 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Environmental Science and Pollution Research; v. 28, n. 8 NOV 2020.
• Citações Web of Science: 0

Resumo

It has been observed that air pollution can affect newborn health due to the negative effects of pollutants on pregnancy development. However, few studies have evaluated the impact of maternal exposure to urban air pollution on head circumference (HC) at birth. Reduced head growth during pregnancy may be associated with neurocognitive deficits in childhood. The objectives of this study were to evaluate the association between maternal exposure to air pollution and HC at birth and to provide context with a systematic review to investigate this association. This was a prospective study of low-risk pregnant women living in Sao Paulo, Brazil. Exposure to pollutants, namely, nitrogen dioxide (NO2) and ozone (O-3), was measured during each trimester using passive personal samplers. We measured newborn HC until 24 h after birth. We used multiple linear regression models to evaluate the association between pollutants and HC while controlling for known determinants of pregnancy. To perform the systematic review, four different electronic databases were searched through November 2018: CENTRAL, EMBASE, LILACS, and MEDLINE. We selected longitudinal or transversal designs associating air pollution and HC at birth. Two reviewers evaluated the inclusion criteria and risk of bias and extracted data from the included papers. Thirteen studies were selected for the systematic review. We evaluated 391 patients, and we did not observe a significant association between air pollution and HC. Regarding the systematic review, 13 studies were selected for the systematic review, 8 studies showed an inverse association between maternal exposure to pollutants and HC, 4 showed no association, and one observed a direct association. In the city of Sao Paulo, maternal exposure to pollutants was not significantly associated with HC at birth. The systematic review suggested an inverse association between air pollution and HC at birth. (AU)

• Processo FAPESP: 08/57717-6 - Instituto Nacional de Análise Integrada de Risco Ambiental
• Beneficiário: Thais Mauad
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 16/14433-4 - Associação entre a exposição materna à poluição na cidade de São Paulo e desfechos do parto e crescimento do polo cefálico
• Beneficiário: Mariana Azevedo Carvalho
• Modalidade de apoio: Bolsas no Brasil - Doutorado