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Roche, Johanna
[1, 2, 3, 4]
;
Corgosinho, Flavia Campos
[5]
;
Isacco, Laurie
[1]
;
Scheuermaier, Karine
[4]
;
Pereira, Bruno
[6]
;
Gillet, Valerie
[2]
;
Moreira, Gustavo A.
[7, 8]
;
Pradella-Hallinan, Marcia
[7, 8]
;
Tufik, Sergio
[7]
;
de Mello, Marco Tulio
[9]
;
Mougin, Fabienne
[1]
;
Damaso, Ana R.
[8]
;
Thivel, David
[3, 10]
Número total de Autores: 13
|
| Afiliação do(s) autor(es): | [1] Univ Bourgogne Franche Comte, Exercise Performance Hlth Innovat Platform, EA3920, Blvd Fleming, Besancon - France
[2] Sleep & Hlth Med Ctr Ellipse, Besancon - France
[3] Univ Clermont Auvergne, Lab Metab Adaptat Exercise Physiol & Pathol Condi, EA3533, Clermont Ferrand - France
[4] Univ Witwatersrand, Fac Hlth Sci, Sch Physiol, Wits Sleep Lab, Brain Funct Res Grp, ZA-2193 Johannesburg, Gauteng - South Africa
[5] Univ Fed Goias, Fac Nutr, Programa Posgrad Nutr, Sao Paulo - Brazil
[6] Clermont Ferrand Univ Hosp, Biostat Unit DRCI, Clermont Ferrand - France
[7] Univ Fed Sao Paulo, Escola Paulista Med, Dept Psicobiol, Sao Paulo - Brazil
[8] Univ Fed Sao Paulo, Escola Paulista Med, Programa Posgrad Nutr, Sao Paulo - Brazil
[9] Univ Fed Minas Gerais, Programa Posgrad Educ Fis, Belo Horizonte, MG - Brazil
[10] Auvergne Res Ctr Human Nutr CRNH, 58 Rue Montalembert, F-63009 Clermont Ferrand - France
Número total de Afiliações: 10
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Sleep Medicine; v. 75, p. 225-235, NOV 2020. |
| Citações Web of Science: | 0 |
| Resumo | |
Objectives: Pediatric obesity and sleep-disordered breathing (SDB) are strongly associated, and both promote metabolic impairments. However, the effects of a lifestyle intervention on the overall metabolic syndrome (MetS) are unknown. The objectives were i) to evaluate the effects of a lifestyle intervention on cardiometabolic risk (CMR), assessed with a dichotomous (MetS) and a continuous (MetScoreFM) in-strument, in obese adolescents with and without SDB and ii) to compare the post-intervention cardiometabolic responses between adolescents with persistent (apnea-hypopnea index; AHI 2) or normalized-SDB (AHI<2). Methods: Seventy-six adolescents with obesity recruited from two specialized institutions underwent a 9-12month diet and exercise intervention. Sleep and SDB (AHI>2) were studied by polysomnography. Anthropometric parameters, fat mass (FM), glucose, insulin, lipid and leptin profiles, blood pressure (BP), MetScoreFM and MetS were assessed preand post-intervention. We performed comparisons between Non-SDB and SDB groups and between Normalized-SDB and Persistent-SDB subgroups. Results: Fifty participants completed the study. Pre-intervention, twenty youth had SDB (40%) with higher insulin concentrations and systolic BP than Non-SDB participants (p < 0.01), for a similar degree of obesity. Post-intervention, MetScoreFM (p < 0.001) and MetS prevalence (p < 0.05) were decreased in both groups. Eleven participants (55%) normalized SDB along with a decrease in insulin concentrations and BP (p < 0.05). Triglycerides, total cholesterol and LDL-cholesterol concentrations (p < 0.01) improved equally in the Normalized and Persistent-SDB subgroups. Conclusion: SDB was associated with lower insulin sensitivity and higher BP but did not affect the lipid profile. A diet and exercise lifestyle intervention is effective in decreasing the CMR whether or not SDB was normalized in obese adolescents. (c) 2020 Elsevier B.V. All rights reserved. (AU) | |
| Processo FAPESP: | 11/50414-0 - Influência da hiperleptinemia nas respostas inflamatórias e aterogênicas em adolescentes obesos |
| Beneficiário: | Ana Raimunda Dâmaso |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 08/53069-0 - Efeitos do tratamento multidisciplinar em adolescentes obesos com esteatose hepática não alcoólica e sua relação com as adipocitocinas pró e anti-inflamatórias |
| Beneficiário: | Ana Raimunda Dâmaso |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 11/50356-0 - Análise de complemento protéico plasmático e de fatores de risco metabólicos em adolescentes obesos em tratamento no Centro de Recuperação e Educação Nutricional (CREN) |
| Beneficiário: | Ana Raimunda Dâmaso |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 13/04136-4 - Análise da regulação neuroendócrina do balanço energético e fatores inflamatórios em obesos adultos submetidos à cirurgia bariátrica |
| Beneficiário: | Ana Raimunda Dâmaso |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 06/00684-3 - Fatores orexígenos, anorexígenos, pró e anti-inflamatórios: efeitos do programa multidisciplinar para redução da massa corporal em adolescentes obesos |
| Beneficiário: | Ana Raimunda Dâmaso |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |