Genetic Landscape of Papillary Thyroid Carcinoma and Nuclear Architecture: An Overview Comparing Pediatric and Adult Populations

Autor(es)

Rangel-Pozzo, Aline ^[1] ; Sisdelli, Luiza ^[2] ; Cordioli, Maria Isabel V. ^[2] ; Vaisman, Fernanda ^[3] ; Caria, Paola ^[4] ; Mai, Sabine ^[1] ; Cerutti, Janete M. ^[2]

Afiliação do(s) autor(es)

^[1] Univ Manitoba, Res Inst Oncol & Hematol, Cell Biol, CancerCare Manitoba, Winnipeg, MB R3E 0V9 - Canada

^[2] Univ Fed Sao Paulo EPM, Genet Bases Thyroid Tumors Lab, Div Genet, Dept Morphol & Genet, BR-04039032 Sao Paulo, SP - Brazil

^[3] Inst Nacl Canc, BR-22451000 Rio De Janeiro, RJ - Brazil

^[4] Univ Cagliari, Dept Biomed Sci, I-09042 Cagliari - Italy

• Tipo de documento: Artigo de Revisão
• Fonte: CANCERS; v. 12, n. 11 NOV 2020.
• Citações Web of Science: 0

Resumo

Simple Summary Papillary thyroid carcinoma (PTC) represents 80-90% of all differentiated thyroid carcinomas. PTC has a high rate of gene fusions and mutations, which can influence clinical and biological behavior in both children and adults. In this review, we focus on the comparison between pediatric and adult PTC, highlighting genetic alterations, telomere-related genomic instability and changes in nuclear organization as novel biomarkers for thyroid cancers. Thyroid cancer is a rare malignancy in the pediatric population that is highly associated with disease aggressiveness and advanced disease stages when compared to adult population. The biological and molecular features underlying pediatric and adult thyroid cancer pathogenesis could be responsible for differences in the clinical presentation and prognosis. Despite this, the clinical assessment and treatments used in pediatric thyroid cancer are the same as those implemented for adults and specific personalized target treatments are not used in clinical practice. In this review, we focus on papillary thyroid carcinoma (PTC), which represents 80-90% of all differentiated thyroid carcinomas. PTC has a high rate of gene fusions and mutations, which can influence the histologic subtypes in both children and adults. This review also highlights telomere-related genomic instability and changes in nuclear organization as novel biomarkers for thyroid cancers. (AU)

• Processo FAPESP: 14/06570-6 - Sequenciamento completo do exoma, Paired-end RNA e genoma: novos insights sobre a natureza genética do câncer de tiróide na idade adulta e na faixa etária pediátrica e aplicações na prática clínica
• Beneficiário: Janete Maria Cerutti
• Modalidade de apoio: Auxílio à Pesquisa - Temático