Calorie restriction changes muscle satellite cell proliferation in a manner independent of metabolic modulation

Autor(es)

Abreu, Phablo ^[1] ; Serna, Julian D. C. ^[1] ; Munhoz, Ana C. ^[1] ; Kowaltowski, Alicia J. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Quim, Dept Bioquim, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: MECHANISMS OF AGEING AND DEVELOPMENT; v. 192, DEC 2020.
• Citações Web of Science: 0

Resumo

Calorie restriction is known to promote healthy aging, which includes prevention of muscle loss. We investigated the effect of rodent calorie restriction on mitochondrial respiration and clonogenic capacity of muscle satellite stem cells, since metabolic alterations are known to regulate stem cell activity. Surprisingly, short or long-term calorie restriction do not change mitochondrial or glycolytic function. Nevertheless, both short- and long-term calorie restriction enhance myogenic colony formation. Overall, our results show that not all changes in satellite stem cell function are accompanied by metabolic remodeling. (AU)

• Processo FAPESP: 13/07937-8 - Redoxoma
• Beneficiário: Ohara Augusto
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 16/18633-8 - Expansão do pool de células satélites no músculo esquelético adulto: papel das alterações bioenergéticas e mitocondriais induzidas pelo exercício físico aeróbio
• Beneficiário: Phablo Sávio Abreu Teixeira
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado