Calorie restriction changes muscle satellite cell proliferation in a manner independent of metabolic modulation

Author(s)

Abreu, Phablo ^[1] ; Serna, Julian D. C. ^[1] ; Munhoz, Ana C. ^[1] ; Kowaltowski, Alicia J. ^[1]

Affiliation

^[1] Univ Sao Paulo, Inst Quim, Dept Bioquim, Sao Paulo - Brazil

• Document type: Journal article
• Source: MECHANISMS OF AGEING AND DEVELOPMENT; v. 192, DEC 2020.
• Web of Science Citations: 0

Abstract

Calorie restriction is known to promote healthy aging, which includes prevention of muscle loss. We investigated the effect of rodent calorie restriction on mitochondrial respiration and clonogenic capacity of muscle satellite stem cells, since metabolic alterations are known to regulate stem cell activity. Surprisingly, short or long-term calorie restriction do not change mitochondrial or glycolytic function. Nevertheless, both short- and long-term calorie restriction enhance myogenic colony formation. Overall, our results show that not all changes in satellite stem cell function are accompanied by metabolic remodeling. (AU)

• FAPESP's process: 13/07937-8 - Redoxome - Redox Processes in Biomedicine
• Grantee: Ohara Augusto
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
• FAPESP's process: 16/18633-8 - Expansion of satellite cell pools in adult skeletal muscle: role of bioenergetics and mitochondrial alterations induced by aerobic exercise
• Grantee: Phablo Sávio Abreu Teixeira
• Support Opportunities: Scholarships in Brazil - Post-Doctoral