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Muscle hypertrophy: resistance training variables versus human biological individuality.

Grant number: 17/05331-6
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): December 01, 2017
Effective date (End): February 28, 2022
Field of knowledge:Health Sciences - Physical Education
Principal researcher:Cleiton Augusto Libardi
Grantee:Vitor Angleri
Home Institution: Centro de Ciências Biológicas e da Saúde (CCBS). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil


Resistance-training (RT) is widely recommended for improving health of several populations. However, several aspects involving RT and the affected mechanisms are not well understood, preventing a RT prescription that allows optimizing/maximizing gains in muscle mass (i.e., muscle hypertrophy). Thus, despite it is suggested that the adequate manipulation of RT variables such as load (intensity), number of sets and repetitions (volume), contraction (e.g., eccentric or concentric), rest interval, may optimize/maximize muscle hypertrophy, it remains unknown whether muscle hypertrophy variability between subjects is due the manner that these variables are manipulated or due human biologic variability, which would exclude the influence of RT manipulation. Hence, we propose 10 week of unilateral RT performed by resistance-trained men to analyze the individual biological responsiveness of RT to muscle failure in two conditions: 1) RT performed consistently (RT-CON) - leg 1 (n = 20); 2) RT with variation of load (kg), series, repetitions, type of contraction and rest interval (RT-VAR) - leg 2 (n = 20). There will be analyzed muscle biopsies CSAf and amount of satellite cells (histochemical analysis) and expression of genes (by real time PCR), related to hypertrophy. Our objectives are: 1) to compare the effect of RT performed to muscle failure with variation (RT-VAR) of the RT variables, with a RT protocol also performed until failure, but without variation (RT-CON), in CSAf of fibers type I and II; 2) to compare the intra-subject response of one leg executing the RT-VAR with the other leg performing the RT-CON; and 3) to verify whether individual biological variability can be explained by changes in satellite cell contents and genetic expression of MGF and MRFs (myogen factor 5 [Myf-5] and myogenic factor [MyoD], Myf-6, myogenin and MRF4 ). We hypothesize that: 1) there will be no difference in the hypertrophy of type I and II fibers between RT-VAR and RT-CON; 2) the magnitude of muscular hypertrophy will be more related to biological individuality than the form in which RT is performed; and 3) the content of satellite cells, number of myonuclei and the expression of MGF will be increased in individuals with higher muscle hypertrophy, regardless of the training protocol.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SOLIGON, SAMUEL DOMINGOS; DA SILVA, DEIVID GOMES; ALMEIDA BERGAMASCO, JOAO GUILHERME; ANGLERI, VITOR; MEDALHA JUNIOR, RICARDO ALESSANDRO; DIAS, NATHALIA FERNANDA; NOBREGA, SANMY ROCHA; CESAR, MARCELO DE CASTRO; LIBARDI, CLEITON AUGUSTO. Suspension training vs. traditional resistance training: effects on muscle mass, strength and functional performance in older adults. EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, v. 120, n. 10 JUL 2020. Web of Science Citations: 0.
ANGLERI, V; UGRINOWITSCH, C.; LIBARDI, C. A. Are resistance training systems necessary to avoid a stagnation and maximize the gains muscle strength and hypertrophy?. SCIENCE & SPORTS, v. 35, n. 2 APR 2020. Web of Science Citations: 0.
DAMAS, FELIPE; ANGLERI, VITOR; PHILLIPS, STUART M.; WITARD, OLIVER C.; UGRINOWITSCH, CARLOS; SANTANIELO, NATALIA; SOLIGON, SAMUEL D.; COSTA, LUIZ A. R.; LIXANDRAO, MANOEL E.; CONCEICAO, MIGUEL S.; LIBARDI, CLEITON A. Myofibrillar protein synthesis and muscle hypertrophy individualized responses to systematically changing resistance training variables in trained young men. Journal of Applied Physiology, v. 127, n. 3, p. 806-815, SEP 2019. Web of Science Citations: 1.

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