Nitric oxide (NO) and nanoparticles - Potential small tools for the war against COVID-19 and other human coronavirus infections

Autor(es)

Pieretti, Joana C. ^[1] ; Rubilar, Olga ^{[2, 3]} ; Weller, Richard B. ^[4] ; Tortella, Gonzalo R. ^{[2, 3]} ; Seabra, Amedea B. ^[1]

Afiliação do(s) autor(es)

^[1] Fed Univ ABC UFABC, Ctr Nat & Human Sci CCNH, Av Estados 5001, BR-09210580 Santo Andre, SP - Brazil

^[2] Univ La Frontera, Dept Chem Engn, Temuco - Chile

^[3] Univ La Frontera, Ctr Excelencia Invest Biotecnol Aplicada Medio Am, Temuco - Chile

^[4] Univ Edinburgh, Ctr Inflammat Res, 47 Little France Crescent, Edinburgh EH16 4TJ, Midlothian - Scotland

• Tipo de documento: Artigo de Revisão
• Fonte: VIRUS RESEARCH; v. 291, JAN 2 2021.
• Citações Web of Science: 0

Resumo

The endogenous free radical nitric oxide (NO) plays a pivotal role in the immunological system. NO has already been reported as a potential candidate for use in the treatment of human coronavirus infections, including COVID-19. In fact, inhaled NO has been used in clinical settings for its antiviral respiratory action, and in the regulation of blood pressure to avoid clot formation. In this mini-review, we discuss recent progress concerning the antivirus activity of NO in clinical, pre-clinical and research settings, and its beneficial effects in the treatment of clinical complications in patients infected with coronaviruses and other respiratory viral diseases, including COVID-19. We also highlight promising therapeutic effects of NO donors allied to nanomaterials to combat COVID-19 and other human coronavirus infections. Nanomaterials can be designed to deliver sustained, localized NO release directly at the desired application site, enhancing the beneficial effects of NO and minimizing the side effects. Challenges and perspectives are presented to open new fields of research. (AU)

• Processo FAPESP: 18/08194-2 - Óleo essencial contendo nanopartículas metálicas funcionalizadas com óxido nítrico como estratégia para o controle de patógenos vegetais na agricultura
• Beneficiário: Amedea Barozzi Seabra
• Modalidade de apoio: Auxílio à Pesquisa - Regular