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Fungal Dysbiosis Correlates with the Development of Tumor-Induced Cachexia in Mice

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Jabes, Daniela L. [1] ; de Maria, Yara N. L. F. [1] ; Barbosa, David Aciole [1] ; Santos, Kaltinaitis B. N. H. [1] ; Carvalho, Lucas M. [1] ; Humberto, Ana Carolina [1] ; Alencar, Valquiria C. [1, 2] ; de Oliveira, Regina Costa [1] ; Batista, Jr., Miguel L. [1] ; Menegidio, Fabiano B. [1] ; Nunes, Luiz R. [2]
Número total de Autores: 11
Afiliação do(s) autor(es):
[1] Univ Mogi Cruzes UMC, Nucleo Integrad Biotecnol, BR-08780911 Sao Paulo - Brazil
[2] Univ Fed ABC UFABC, Ctr Ciencias Nat & Humanas, BR-09606045 Sao Bernardo Do Campo - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF FUNGI; v. 6, n. 4 DEC 2020.
Citações Web of Science: 0

Cachexia (CC) is a devastating metabolic syndrome associated with a series of underlying diseases that greatly affects life quality and expectancy among cancer patients. Studies involving mouse models, in which CC was induced through inoculation with tumor cells, originally suggested the existence of a direct correlation between the development of this syndrome and changes in the relative proportions of several bacterial groups present in the digestive tract. However, these analyses have focus solely on the characterization of bacterial dysbiosis, ignoring the possible existence of changes in the relative populations of fungi, during the development of CC. Thus, the present study sought to expand such analyses, by characterizing changes that occur in the gut fungal population (mycobiota) of mice, during the development of cancer-induced cachexia. Our results confirm that cachectic animals, submitted to Lewis lung carcinoma (LLC) transplantation, display significant differences in their gut mycobiota, when compared to healthy controls. Moreover, identification of dysbiotic fungi showed remarkable consistency across successive levels of taxonomic hierarchy. Many of these fungi have also been associated with dysbioses observed in a series of gut inflammatory diseases, such as obesity, colorectal cancer (CRC), myalgic encephalomyelitis (ME) and inflammatory bowel disease (IBD). Nonetheless, the dysbiosis verified in the LLC model of cancer cachexia seems to be unique, presenting features observed in both obesity (reduced proportion of Mucoromycota) and CRC/ME/IBD (increased proportions of Sordariomycetes, Saccharomycetaceae and Malassezia). One species of Mucoromycota (Rhyzopus oryzae) stands out as a promising probiotic candidate in adjuvant therapies, aimed at treating and/or preventing the development of CC. (AU)

Processo FAPESP: 17/08112-3 - Análise da composição e da influência exercida pelo microbioma intestinal de camundongos durante o desenvolvimento de caquexia induzida por transplante de células de câncer pulmonar (LLC)
Beneficiário:Daniela Leite Jabes
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 17/13197-8 - Caracterização de elementos promotores responsivos ao auto-indutor de quorum sensing (QS) tipo 2 (AI-2) em Zymomonas mobilis
Beneficiário:Luiz Roberto Nunes
Linha de fomento: Auxílio à Pesquisa - Programa BIOEN - Regular