Does a high-fat diet affect the circadian clock, or is it the other way around? A systematic review

Autor(es)

Rezende Paula, Ana Beatriz ^[1] ; Miranda, Denise de Coutinho ^[1] ; Nogueira, Franciane Toledo ^[1] ; de Lauro Castrucci, Ana Maria ^[2] ; Isoldi, Mauro Cesar ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Ouro Preto, Inst Exact & Biol Sci, Res Ctr Biol Sci, Lab Cell Signaling, R Quatro 786, BR-35400000 Bauxita, Ouro Preto - Brazil

^[2] Univ Sao Paulo, Inst Biosci, Lab Comparat Physiol Pigmentat, Dept Physiol, R Matao, Trav 14, 101, BR-05508090 Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: Nutrition Research; v. 84, p. 1-13, DEC 2020.
• Citações Web of Science: 0

Resumo

This paper reviews studies that addressed the influence of diet on circadian rhythmicity in mice and, in turn, circadian clock chronodisruption and its role in the development of metabolic disorders. Studies from the past 14 years were selected via a systematic search conducted using the PubMed electronic database. After applying the inclusion and exclusion criteria, 291 studies were selected, of which 13 were chosen using the following inclusion criteria: use of a high-fat diet for mice, evaluation of clock gene expression, and the association between chronodisruption and lipid metabolism disorders. These studies reported changes in animals' biological clock when they developed metabolic disorders by consuming a high-fat diet. It was also evident that some clock gene mutations or deletions triggered metabolic changes. Disturbances of clock gene machinery may play important roles in lipid metabolism and the development of atherosclerotic processes. However, many metabolic processes also affect the function of clock genes and circadian systems. In summary, this review's results may provide new insights into the reciprocal regulation of energy homeostasis and the biological clock. (c) 2020 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 18/14728-0 - Melanopsina como fotorreceptor de UVA e sua relação com pigmentação, reparo de DNA, relógio biológico e componentes do eixo HPA: um novo alvo farmacológico?
• Beneficiário: Ana Maria de Lauro Castrucci
• Modalidade de apoio: Auxílio à Pesquisa - Regular