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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Does a high-fat diet affect the circadian clock, or is it the other way around? A systematic review

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Author(s):
Rezende Paula, Ana Beatriz [1] ; Miranda, Denise de Coutinho [1] ; Nogueira, Franciane Toledo [1] ; de Lauro Castrucci, Ana Maria [2] ; Isoldi, Mauro Cesar [1]
Total Authors: 5
Affiliation:
[1] Univ Fed Ouro Preto, Inst Exact & Biol Sci, Res Ctr Biol Sci, Lab Cell Signaling, R Quatro 786, BR-35400000 Bauxita, Ouro Preto - Brazil
[2] Univ Sao Paulo, Inst Biosci, Lab Comparat Physiol Pigmentat, Dept Physiol, R Matao, Trav 14, 101, BR-05508090 Sao Paulo - Brazil
Total Affiliations: 2
Document type: Review article
Source: Nutrition Research; v. 84, p. 1-13, DEC 2020.
Web of Science Citations: 0
Abstract

This paper reviews studies that addressed the influence of diet on circadian rhythmicity in mice and, in turn, circadian clock chronodisruption and its role in the development of metabolic disorders. Studies from the past 14 years were selected via a systematic search conducted using the PubMed electronic database. After applying the inclusion and exclusion criteria, 291 studies were selected, of which 13 were chosen using the following inclusion criteria: use of a high-fat diet for mice, evaluation of clock gene expression, and the association between chronodisruption and lipid metabolism disorders. These studies reported changes in animals' biological clock when they developed metabolic disorders by consuming a high-fat diet. It was also evident that some clock gene mutations or deletions triggered metabolic changes. Disturbances of clock gene machinery may play important roles in lipid metabolism and the development of atherosclerotic processes. However, many metabolic processes also affect the function of clock genes and circadian systems. In summary, this review's results may provide new insights into the reciprocal regulation of energy homeostasis and the biological clock. (c) 2020 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 18/14728-0 - Melanopsin as the UVA photoreceptor and its relationship with pigmentation, DNA repair, biological clock and components of the HPA axis: a novel pharmacological target?
Grantee:Ana Maria de Lauro Castrucci
Support Opportunities: Regular Research Grants