Interference of in utero exposure to di-n-butyl phthalate and excessive consumptio...
| Grant number: | 14/07243-9 |
| Support type: | Scholarships in Brazil - Scientific Initiation |
| Effective date (Start): | July 01, 2014 |
| Effective date (End): | December 31, 2014 |
| Field of knowledge: | Biological Sciences - Biology |
| Principal Investigator: | Rita Luiza Peruquetti |
| Grantee: | Isabela Pazotti Daher |
| Home Institution: | Centro de Ciências da Saúde. Universidade do Sagrado Coração (USC). Bauru , SP, Brazil |
Abstract Biological rhythms are regulatory mechanisms allowing the organisms predicting and changing their physiological and behavioral activities in response to environmental stimulus. Circadian cycles are regulatory responses occurring within a 24 hour period. The central circadian control of the physiological activities is located in the suprachiasmatic nucleus (SNC) in the hypothalamus, but similar mechanisms of circadian control were also found in peripheral tissues (i.e. fat, liver, and gut). From a molecular stand-point, circadian rhythms are regulated by transcriptional and post-translational feedback loops generated by a set of interplaying clock proteins. The two main clock system proteins are CLOCK and BMAL1, which are transcription factors that heterodimerize and induce the expression of clock-controlled genes, such as metabolic genes. Modern lifestyle has a direct effect on the food consumption habits of the population. Alterations on those habits are leading to an increase in the prevalence of metabolic syndromes, such as obesity. It is known that obesity can affect the fertility rates in women population mainly by causing anovulatory menstrual cycle. The ingestion of polyherbal or natural drugs, such as green tea extracts (Camellia sinensis) has been increasing among the population, in the attempting to control obesity problems due its effects on the lipid oxidation and glycemia. The aim of this project is to check the influence of the green tea consumption at different day phases on the glycemia levels, on the body weight control, as well as, on the expression of LXR ovary receptor of obese female diet induced. | |