Oral leukoplakia and erythroplakia in young patients: a systematic review

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Oliveira Correa Roza, Ana Luiza ^[1] ; Kowalski, Luiz Paulo ^[2] ; William Jr, William Nassib ; de Castro Jr, Gilberto ; Freitas Chaves, Aline Lauda ^[3] ; Damaceno Araujo, Anna Luiza ^[1] ; Prado Ribeiro, Ana Carolina ^{[1, 4]} ; Brandao, Thais Bianca ^{[5, 4]} ; Lopes, Marcio Ajudarte ^[1] ; Vargas, Pablo Agustin ^[1] ; Santos-Silva, Alan Roger ^[1] ; Gr, Latin Amer Cooperative Oncology ; Canc, Brazilian Grp Head Neck

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Piracicaba Dent Sch, Oral Diag Dept, Piracicaba - Brazil

^[2] AC Camargo Canc Ctr, Head & Neck Surg Dept, Sao Paulo - Brazil

^[3] DOM Oncol Grp, Divinopolis - Brazil

^[4] Sao Paulo State Canc Inst, Dent Oncol Serv, Sao Paulo - Brazil

^[5] Hosp Sirio Libanes, Oral Med Dept, Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY; v. 131, n. 1, p. 73-84, JAN 2021.
• Citações Web of Science: 0

Resumo

Objective. The aim of this study was to estimate the frequency of oral leukoplakia and oral erythroplakia in young patients. Study Design. The systematic review was based on the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines and performed in the following electronic databases: PubMed, Scopus, and Embase. The studies included were cross-sectional, cohort, and diagnostic, which provided with clinical and microscopic data of patients younger than 40 years. The Critical Appraisal Checklist for Prevalence Studies from the Joanna Briggs Institute and the Quality Assessment Tool for Diagnostic Accuracy Studies were used to assess the risk of bias. Results. Five studies met eligibility criteria and were included. The total number of patients from the studies was 1246, of which 115 were young patients (9.2%) with oral leukoplakia as the only oral potentially malignant disorder reported. Oral epithelial dysplasia was identified in 40 cases (34.7%), of which 8 (6.9%) presented malignant transformation. Conclusions. The frequency of oral leukoplakia is low in young patients. Observational studies are necessary for understanding oral leukoplakia and other oral potentially malignant disorders in younger patients. (AU)

• Processo FAPESP: 18/02233-6 - Segurança oncológica no uso da fotobiomodulação intraoral e extraoral em pacientes com carcinoma espinocelular de cavidade oral e orofaringe
• Beneficiário: Alan Roger dos Santos Silva
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 19/02539-0 - Estudo clinicopatológico multicêntrico e proteômico de tumores odontogênicos adenomatoides
• Beneficiário: Ana Luiza Oliveira Corrêa Roza
• Modalidade de apoio: Bolsas no Brasil - Mestrado