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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Conjugation of superparamagnetic iron oxide nanoparticles and curcumin photosensitizer to assist in photodynamic therapy

Texto completo
Autor(es):
de Santana, Willian Max O. S. [1] ; Caetano, Bruno L. [2, 3, 4] ; de Annunzio, Sarah Raquel [2] ; Pulcinelli, Sandra H. [1] ; Menager, Christine [4] ; Fontana, Carla Raquel [2] ; Santilli, V, Celso
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] V, Sao Paulo State Univ UNESP, Inst Chem, BR-14800900 Araraquara, SP - Brazil
[2] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, BR-14800903 Araraquara, SP - Brazil
[3] Sorbonne Univ, PSL Univ, CNRS, ESPCI Paris, Soft Matter Sci & Engn, F-75005 Paris - France
[4] Sorbonne Univ, CNRS, PHENIX, Physicochim Electrolytes & Nanosyst Interfaciaux, F-75005 Paris - France
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: COLLOIDS AND SURFACES B-BIOINTERFACES; v. 196, DEC 2020.
Citações Web of Science: 0
Resumo

In this work, we describe the synthesis and characterization of the SPIONP-CUR conjugate between curcumin (CUR) and superparamagnetic iron oxide nanoparticles (SPIONPs), in addition to its application in photo-dynamic therapy (PDT) using a protocol free of organic solvents as a dispersant. The SPIONP-CUR conjugate was characterized by X-ray diffraction, transmission electron microscopy, zeta potential measurements, Fourier transform infrared spectroscopy, thermogravimetry, magnetometry and magnetic hyperthermia assays. The SPIONP-CUR conjugation occurred by bonding between the keto-enol moiety of CUR and the iron atoms present on the surfaces of the SPIONPs. The conjugate showed heating power under an alternating magnetic field (AMF) and photodynamic action when irradiated with blue LED light. In experiments using PDT against Staphylococcus aureus in the planktonic phase, it was demonstrated that with application of blue light at 3.12 J cm(-2), the conjugate (dispersed in water) caused a total reduction of the bacterial load. In the absence of light, the reduction was insignificant, even after 24 h of contact with the bacteria. (AU)

Processo FAPESP: 18/23015-7 - Terapia fotodinâmica antimicrobiana via irradiação em modo contínuo e chaveado contra Enterococcus faecalis e Cutibacterium acnes
Beneficiário:Carla Raquel Fontana Mendonça
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 18/09088-1 - Avaliação da terapia fotodinâmica contra biofilmes acneicos polimicrobianos: um estudo pré-clínico
Beneficiário:Sarah Raquel de Annunzio
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 17/07822-7 - Conjugação de nanopartículas superparamagnéticas de óxido de ferro e curcumina: associação da terapia fotodinâmica e hipertermia magnética
Beneficiário:Willian Max Oliveira de Souza de Santana
Linha de fomento: Bolsas no Brasil - Mestrado