Sustainable Single-Stage Solid-Liquid Extraction of Hesperidin and Rutin from Agro-Products Using Cyrene

Autor(es)

Milescu, Roxana Alina ^[1] ; Segatto, Mateus Lodi ^[2] ; Stahl, Aylon ^[2] ; McElroy, Con Robert ^[1] ; Farmer, Thomas James ^[1] ; Clark, James Hanley ^[1] ; Zuin, Vania Gomes ^{[2, 1, 3]}

Afiliação do(s) autor(es)

^[1] Univ York, Green Chem Ctr Excellence, Dept Chem, York YO10 5DD, N Yorkshire - England

^[2] Univ Fed Sao Carlos, Dept Chem, BR-13565905 Sao Carlos, SP - Brazil

^[3] Leuphana Univ Luneburg, Inst Sustainable & Environm Chem, C13-204, Luneburg - Germany

• Tipo de documento: Artigo Científico
• Fonte: ACS SUSTAINABLE CHEMISTRY & ENGINEERING; v. 8, n. 49, p. 18245-18257, DEC 14 2020.
• Citações Web of Science: 5

Resumo

Hesperidin and rutin are two sought-after natural flavonoids, traditionally extracted from abundant natural citrus fruits and tea leaves using large amounts of ethanol or methanol solvents. Recent trends in extractions have focused on minimizing the use of solvents and creating simpler cost-effective processes. This study aims to apply the concept of chemical valorization in the context of a circular economy, by using agro-industrial waste and biobased alternatives to traditional solvents, which are of environmental concern. We use minimum amounts of solvent/sample (5 mL/0.25 or 0.5 g) to extract hesperidin and rutin in a single-stage solid-liquid extraction. Thirty individual solvents and HSPiP were applied to find the best solvents/blends for extraction. The type of solvent, sample preparation, maceration time, and extraction temperature were studied. Results showed that the biobased solvent Cyrene is very effective when mildly heated to 65 degrees C (up to 91%) or mixed with water. Adding water to Cyrene forms its geminal diol hydrate, this enhances the solubility and extraction of hesperidin and rutin up to ten times than those of the original pure ketone form. Quantitative sustainability metrics from the CHEM21 Toolkit demonstrated that our extraction methodology is environmentally friendly and offers future potential of isolation of other flavonoids. (AU)

• Processo FAPESP: 17/25015-1 - Desenho e aplicação de métodos verdes para a extração de compostos orgânicos de alto valor agregado derivados de biomassa residual agroindustrial
• Beneficiário: Vânia Gomes Zuin Zeidler
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 14/50827-1 - Compostos obtidos a partir de resíduos de laranja: contribuições da abordagem integrada de biorrefinaria para o desenvolvimento sustentável no Brasil
• Beneficiário: João Batista Fernandes
• Modalidade de apoio: Auxílio à Pesquisa - Regular