Characterization of novel polydiacetylene gel dosimeter for radiotherapy

Autor(es)

Walg, Y. Peleg ^{[1, 2]} ; Silveira, M. A. ^[3] ; Eafergan, N. ^[1] ; Krutman, Y. ^[4] ; Baffa, O. ^[3] ; Berman, A. ^[1] ; Orion, I ^[2]

Afiliação do(s) autor(es)

^[1] Ben Gurion Univ Negev, Dept Biotechnol Engn, IL-84105 Beer Sheva - Israel

^[2] Ben Gurion Univ Negev, Dept Nucl Engn, IL-84105 Beer Sheva - Israel

^[3] Univ Sao Paulo, FFCLRP, Dept Fis, Av Bandeirantes 3900, BR-14040901 Ribeirao Preto, SP - Brazil

^[4] Soroka Univ, Med Ctr, Inst Oncol, Radiotherapy Dept, IL-84100 Beer Sheva - Israel

• Tipo de documento: Artigo Científico
• Fonte: BIOMEDICAL PHYSICS & ENGINEERING EXPRESS; v. 6, n. 5 SEP 2020.
• Citações Web of Science: 0

Resumo

Polymer gel dosimeters are instrumental for clinical and research applications in radiotherapy. These dosimeters possess the unique ability to record dose distribution in three dimensions. A Polymer gel dosimeter is composed of organic molecules in a gel matrix, which upon irradiation polymerize to form a conjugated polymer with optical absorbance proportional to the irradiated dose. Other required characteristics of a radiotherapy clinical dosimeter are soft-tissue equivalency, linear dose-response in a range of clinical treatments, and long term stability for the duration of the analysis. The dosimeter presented in this paper is based on diacetylene bearing fatty acid aggregates embedded in a soft-tissue equivalent gel matrix, Phytagel (TM), which upon irradiation polymerize to form a blue phase polydiacetylene with a strong optical absorption. Initial characterization showed that PDA-gel irradiated with 160 kV x-ray responded linearly to the irradiated dose, and the calculated diffusion coefficient is 6.10(-3)mm(2)/Hr what is very low. It was also found that the percentage depth dose (PDD) curve of the PDA-gel in a 4 x 4 cm(2) field, irradiated with 6 MV x-rays, was with good agreement with the literature. PDA-gel has the potential to detect absorbed dose in a range of clinical radiological irradiation regimes. (AU)

• Processo FAPESP: 13/07699-0 - Centro de Pesquisa, Inovação e Difusão em Neuromatemática - NeuroMat
• Beneficiário: Oswaldo Baffa Filho
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 15/18221-9 - Desenvolvimento de um protocolo clínico para implementação do dosímetro gel Magic-f ou equivalente para realizar controle de qualidade em radioterapia
• Beneficiário: Oswaldo Baffa Filho
• Modalidade de apoio: Auxílio à Pesquisa - Pesquisador Visitante - Internacional