Genetic polymorphisms associated with upper gastrointestinal bleeding: a systematic review

Autor(es)

Forgerini, Marcela ^[1] ; Lucchetta, Rosa Camila ^[1] ; Urbano, Gustavo ^[2] ; de Nadai, Tales Rubens ^[3] ; de Carvalho Mastroianni, Patricia ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Drugs & Med, Araraquara, SP - Brazil

^[2] Univ Sao Paulo, Sch Med, Dept Surg, Ribeirao Preto - Brazil

^[3] Univ Sao Paulo, Bauru Sch Dent, Dept Publ Hlth, Bauru, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: PHARMACOGENOMICS JOURNAL; v. 21, n. 1, p. 20-36, FEB 2021.
• Citações Web of Science: 0

Resumo

Non-variceal upper gastrointestinal bleeding (non-variceal UGIB) is a frequent and severe adverse drug reaction. Idiosyncratic responses due to genetic susceptibility to non-variceal UGIB has been suggested. A systematic review was conducted to assess the association between genetic polymorphisms and non-variceal UGIB. Twenty-one publications and 7134 participants were included. Thirteen studies evaluated genetic polymorphism in patients exposed to non-steroidal anti-inflammatory drugs, low-dose aspirin, and warfarin. Eight studies present at least one methodological problem. Only six studies clearly defined that the outcome evaluated was non-variceal UGIB. Genetic polymorphisms involved in platelet activation and aggregation, angiogenesis, inflammatory process, and drug metabolism were associated with risk of non-variceal UGIB (NOS3, COX-1;COX-2;PLA2G7;GP1BA;GRS;IL1RN;F13A1;CDKN2B-AS1;DPP6;TBXA2R;TNF-alph a;VKORC1;CYP2C9;andAGT). Further well-designed studies are needed (e.g., clear restriction to non-variceal UGIB; proper selection of participants; and adjustment of confounding factors) to provide strong evidence for pharmacogenetic and personalized medicine. (AU)

• Processo FAPESP: 18/07501-9 - Determinantes genéticos da hemorragia gastrointestinal associada ao uso do ácido acetilsalicílico como agente antiplaquetário: um estudo caso-controle
• Beneficiário: Marcela Forgerini
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 17/24193-3 - Determinantes genéticos da hemorragia gastrointestinal associada ao uso de ácido acetilsalicílico como agente antiplaquetário: um estudo de caso-controle
• Beneficiário: Patricia de Carvalho Mastroianni
• Modalidade de apoio: Auxílio à Pesquisa - Regular