| Texto completo | |
| Autor(es): |
Forgerini, Marcela
[1]
;
Lucchetta, Rosa Camila
[1]
;
Urbano, Gustavo
[2]
;
de Nadai, Tales Rubens
[3]
;
de Carvalho Mastroianni, Patricia
[1]
Número total de Autores: 5
|
| Afiliação do(s) autor(es): | [1] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Drugs & Med, Araraquara, SP - Brazil
[2] Univ Sao Paulo, Sch Med, Dept Surg, Ribeirao Preto - Brazil
[3] Univ Sao Paulo, Bauru Sch Dent, Dept Publ Hlth, Bauru, SP - Brazil
Número total de Afiliações: 3
|
| Tipo de documento: | Artigo de Revisão |
| Fonte: | PHARMACOGENOMICS JOURNAL; v. 21, n. 1, p. 20-36, FEB 2021. |
| Citações Web of Science: | 0 |
| Resumo | |
Non-variceal upper gastrointestinal bleeding (non-variceal UGIB) is a frequent and severe adverse drug reaction. Idiosyncratic responses due to genetic susceptibility to non-variceal UGIB has been suggested. A systematic review was conducted to assess the association between genetic polymorphisms and non-variceal UGIB. Twenty-one publications and 7134 participants were included. Thirteen studies evaluated genetic polymorphism in patients exposed to non-steroidal anti-inflammatory drugs, low-dose aspirin, and warfarin. Eight studies present at least one methodological problem. Only six studies clearly defined that the outcome evaluated was non-variceal UGIB. Genetic polymorphisms involved in platelet activation and aggregation, angiogenesis, inflammatory process, and drug metabolism were associated with risk of non-variceal UGIB (NOS3, COX-1;COX-2;PLA2G7;GP1BA;GRS;IL1RN;F13A1;CDKN2B-AS1;DPP6;TBXA2R;TNF-alph a;VKORC1;CYP2C9;andAGT). Further well-designed studies are needed (e.g., clear restriction to non-variceal UGIB; proper selection of participants; and adjustment of confounding factors) to provide strong evidence for pharmacogenetic and personalized medicine. (AU) | |
| Processo FAPESP: | 18/07501-9 - Determinantes genéticos da hemorragia gastrointestinal associada ao uso do ácido acetilsalicílico como agente antiplaquetário: um estudo caso-controle |
| Beneficiário: | Marcela Forgerini |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado Direto |
| Processo FAPESP: | 17/24193-3 - Determinantes genéticos da hemorragia gastrointestinal associada ao uso de ácido acetilsalicílico como agente antiplaquetário: um estudo de caso-controle |
| Beneficiário: | Patricia de Carvalho Mastroianni |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |